Enviar artigo por via de e-mail Study of heme and globin conformation in fractionated rat erythrocytes by means of raman spectroscopy
- Autores: Yushkov B.1,2, Zuev M.3, Brilliant S.1,2, Vasin A.3
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Afiliações:
- Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
- GAUZ SO “Institute for Medical Cell Technologies”
- Institute of Solid State Chemistry, Ural Branch of the Russian Academy of Sciences
- Edição: Volume 68, Nº 1 (2023)
- Páginas: 33-40
- Seção: Articles
- URL: https://journals.rcsi.science/0006-3029/article/view/144402
- DOI: https://doi.org/10.31857/S0006302923010040
- EDN: https://elibrary.ru/NZMURQ
- ID: 144402
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Resumo
Conformational changes of heme and globin in fractionated rat erythrocytes have been investigated using Raman spectroscopy. The results obtained show that normal isoforms (common variants) of hemoglobin, which plays a key role in oxygen transport and a protective role against oxidative stress, are dominant (more than 80%) in rat blood. However, heavy chain (3%) and light chain isoforms (11%) formed as a result of protein polymerization or degradation perform important roles in the body because they also function in signal transmission and binding to exogenous ligands.
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Sobre autores
B. Yushkov
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences;GAUZ SO “Institute for Medical Cell Technologies”Yekaterinburg, Russia
M. Zuev
Institute of Solid State Chemistry, Ural Branch of the Russian Academy of SciencesYekaterinburg, Russia
S. Brilliant
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences;GAUZ SO “Institute for Medical Cell Technologies”
Email: svetlana.brilliant@bk.ru
Yekaterinburg, Russia
A. Vasin
Institute of Solid State Chemistry, Ural Branch of the Russian Academy of SciencesYekaterinburg, Russia
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