Email this article Analysis of coverage of Alu repeats by aligned genomic reads
- Authors: Tamazian G.S1, Kanapin A.A1, Samsonova A.A1
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Affiliations:
- Institute of Translational Biomedicine, St. Petersburg State University
- Issue: Vol 68, No 3 (2023)
- Pages: 496-500
- Section: Articles
- URL: https://journals.rcsi.science/0006-3029/article/view/144450
- DOI: https://doi.org/10.31857/S0006302923030109
- EDN: https://elibrary.ru/FRPXRZ
- ID: 144450
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Abstract
Alu repeats occupy a notable part of the human genome and greatly affect processes related to genome integrity maintenance. One of the basic methods for studying variation in a genome, including Alu repeats is genome sequencing followed by mapping the sequenced reads to a reference genome sequence. The key feature of the read alignment is the depth of reference genome region coverage by mapped reads. In this paper, a new method is proposed for analyzing the coverage of Alu repeats and their flanking regions by whole-genome sequencing reads and the distribution of mean coverage in two aforementioned region types is explored.
Keywords
About the authors
G. S Tamazian
Institute of Translational Biomedicine, St. Petersburg State UniversitySt. Petersburg, Russia
A. A Kanapin
Institute of Translational Biomedicine, St. Petersburg State UniversitySt. Petersburg, Russia
A. A Samsonova
Institute of Translational Biomedicine, St. Petersburg State University
Email: a.samsonova@spbu.ru
St. Petersburg, Russia
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