Email this article Physicochemical properties and composition of the liposome lipids from lecithin depending on conditions that lead to the formation of liposome lipids
- Authors: Shishkina L.N1, Paramonov D.V2, Klimovich M.A1, Kozlov M.V1
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Affiliations:
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- State Scientific Research Institute of Biological Engineering
- Issue: Vol 68, No 6 (2023)
- Pages: 1172-1179
- Section: Articles
- URL: https://journals.rcsi.science/0006-3029/article/view/249684
- DOI: https://doi.org/10.31857/S000630292306008X
- EDN: https://elibrary.ru/ROQFPU
- ID: 249684
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Abstract
The effects of the composition and physicochemical properties of lecithin lipids, ultrasound exposure and centrifugation time on the composition and physicochemical properties of liposomes formed from lecithin were studied. It was found that the intensity of lipid peroxidation of liposomes is interrelated by the reversal correlation with the phospholipids share in the total lipid composition of lecithin and the direct correlation with the relative content of cardiolipin in the lecithin phospholipid composition. It was shown that ultrasound exposure and centrifugation produce stage changes in the composition and properties of the liposome lipids. Decreases in the levels of medium pH and the intensity of lipid peroxidation of liposomes were observed under centrifugal conditions. It was found that the stage changes in the ability of liposome lipids for oxidation depending on the time of ultrasound exposure and centrifugation are due to the relative changes in the sum share of the acid minor fractions in the composition of their phospholipids.
Keywords
About the authors
L. N Shishkina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: shishkina@sky.chph.ras.ru
Moscow, Russia
D. V Paramonov
State Scientific Research Institute of Biological EngineeringMoscow, Russia
M. A Klimovich
Emanuel Institute of Biochemical Physics, Russian Academy of SciencesMoscow, Russia
M. V Kozlov
Emanuel Institute of Biochemical Physics, Russian Academy of SciencesMoscow, Russia
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