Email this article High- dose nitric oxide gas inhalation for HIV infection
- Authors: Pekshev A.V1, Vagapov A.B1, Sharapov N.A1, Vanin A.F2
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Affiliations:
- N.E. Bauman Moscow State Technical University
- N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
- Issue: Vol 68, No 5 (2023)
- Pages: 1074-1080
- Section: Articles
- URL: https://journals.rcsi.science/0006-3029/article/view/233485
- DOI: https://doi.org/10.31857/S0006302923050289
- EDN: https://elibrary.ru/NBAREQ
- ID: 233485
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Abstract
Therapeutic effect of high-dose nitric oxide gas inhalation (NO concentration was not less than than 1000 ppm) on two patients with HIV infection was shown. Inhaled NO therapy led to a rapid decrease in viral load to an undetectable level which was persistent even after analytical treatment interruption. It is suggested that HIV infection is controlled by nitrosonium (NO+) cations, the oxidized form of neutral NO molecules that enter the blood. Subsequent conversion of NO+ cations into nitrite anions due to a reaction with hydroxyl ions is inhibited by the binding of NO+ cations and chloride anions leading to the formation of nitrosyl chloride in the blood. Further entry of nitrosyl chloride into cells and tissues ensures NO+ transfer to them. Interaction between nitrosyl chloride and thiols requires the appearance of relevant S-nitrosothiols as NO donors in cells and tissues.
About the authors
A. V Pekshev
N.E. Bauman Moscow State Technical UniversityMoscow, Russia
A. B Vagapov
N.E. Bauman Moscow State Technical UniversityMoscow, Russia
N. A Sharapov
N.E. Bauman Moscow State Technical UniversityMoscow, Russia
A. F Vanin
N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
Email: vanin.dnic@gmail.com
Moscow, Russia
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