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Dinitrosyl iron complexes with thiol-containing ligands as sources of universal cytotoxins - nitrosonium cations
- Authors: Vanin A.F1, Tkachev N.A1
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Affiliations:
- N.N. Semenov Federal Research Center for Chemical Physics
- Issue: Vol 68, No 3 (2023)
- Pages: 421-434
- Section: Articles
- URL: https://journals.rcsi.science/0006-3029/article/view/144441
- DOI: https://doi.org/10.31857/S0006302923030018
- EDN: https://elibrary.ru/FPGKAY
- ID: 144441
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Abstract
It was shown that the release of a half of nitrosyl ligands from dinitrosyl iron units in the form of nitrosonium cation (NO+) from binuclear dinitrosyl iron complexes with thiol-containing ligands (B-DNIC) during DNIC decomposition in acid solutions is increased with the decrease of the stability of these complexes and completely blocked with the increase of the concentrations of free thiols (non-included into B-DNIC) up to the level that was two times and more than that of dinitrosyl iron units. It was demonstrated that the less stable B-DNIC with mercaptosuccinate degrade in an acidic environment at ambient temperature, while the decomposition of more stable B-DNIC with glutathione was only marked when the solution was heated at 80°C. The inhibition of NO+ release from B-DNIC in the presence of elevated free thiol level in the solution was due to the ability of free thiols to induce the reduction of NO+ to NO.
About the authors
A. F Vanin
N.N. Semenov Federal Research Center for Chemical Physics
Email: vanin.dnic@gmail.com
Moscow, Russia
N. A Tkachev
N.N. Semenov Federal Research Center for Chemical PhysicsMoscow, Russia
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