Age peculiarities in the effect of stimulation of α2-adrenergic receptor on electrical activity of rat cardiomyocytes

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Abstract

Clonidine hydrochloride, an agonist of the α2-adrenergic receptor, was tested for its effect on the parameters of the electrical activity of the atrial myocardium induced by pacing. In the experimental rat cardiomyocyte pacing model, clonidine hydrochloride caused a decrease (approximately 50% and 90%) in action potential duration in adult rats. Treatment of one- and three-week-old rats with this agonist led to an increase (around 50% and 90%) in action potential duration

About the authors

A. M Galieva

Kazan Federal University

Email: galieva_alina94@mail.ru
Kazan, Russia

N. I Ziyatdinova

Kazan Federal University

Kazan, Russia

N. Mansour

Kazan Federal University

Kazan, Russia

L. I Fashutdinov

Kazan Federal University

Kazan, Russia

T. L Zefirov

Kazan Federal University

Kazan, Russia

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