Structure and Functions of the Mediator Complex

E. V. Putlyaev; A. N. Ibragimov; L. A. Lebedeva; P. G. Georgiev; Y. V. Shidlovskii

doi:10.1134/S0006297918040132

Structure and Functions of the Mediator Complex

作者: Putlyaev E.¹, Ibragimov A.¹, Lebedeva L.¹, Georgiev P.¹, Shidlovskii Y.¹^,2
隶属关系:
1. Institute of Gene Biology
2. Sechenov First Moscow State Medical University
期: 卷 83, 编号 4 (2018)
页面: 423-436
栏目: Review
URL: https://journals.rcsi.science/0006-2979/article/view/151640
DOI: https://doi.org/10.1134/S0006297918040132
ID: 151640

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详细

Mediator is a key factor in the regulation of expression of RNA polymerase II-transcribed genes. Recent studies have shown that Mediator acts as a coordinator of transcription activation and participates in maintaining chromatin architecture in the cell nucleus. In this review, we present current concepts on the structure and functions of Mediator.