Structure and Functions of the Mediator Complex

E. V. Putlyaev; A. N. Ibragimov; L. A. Lebedeva; P. G. Georgiev; Y. V. Shidlovskii

doi:10.1134/S0006297918040132

Structure and Functions of the Mediator Complex

Authors: Putlyaev E.V.¹, Ibragimov A.N.¹, Lebedeva L.A.¹, Georgiev P.G.¹, Shidlovskii Y.V.¹^,2
Affiliations:
1. Institute of Gene Biology
2. Sechenov First Moscow State Medical University
Issue: Vol 83, No 4 (2018)
Pages: 423-436
Section: Review
URL: https://journals.rcsi.science/0006-2979/article/view/151640
DOI: https://doi.org/10.1134/S0006297918040132
ID: 151640

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Statistics

Abstract

Mediator is a key factor in the regulation of expression of RNA polymerase II-transcribed genes. Recent studies have shown that Mediator acts as a coordinator of transcription activation and participates in maintaining chromatin architecture in the cell nucleus. In this review, we present current concepts on the structure and functions of Mediator.