Structure and Functions of the Mediator Complex

E. V. Putlyaev; A. N. Ibragimov; L. A. Lebedeva; P. G. Georgiev; Y. V. Shidlovskii

doi:10.1134/S0006297918040132

Structure and Functions of the Mediator Complex

Autores: Putlyaev E.¹, Ibragimov A.¹, Lebedeva L.¹, Georgiev P.¹, Shidlovskii Y.¹^,2
Afiliações:
1. Institute of Gene Biology
2. Sechenov First Moscow State Medical University
Edição: Volume 83, Nº 4 (2018)
Páginas: 423-436
Seção: Review
URL: https://journals.rcsi.science/0006-2979/article/view/151640
DOI: https://doi.org/10.1134/S0006297918040132
ID: 151640

Citar

Texto integral

Acesso aberto
Acesso é fechado

Acesso está concedido
Acesso é fechado

Somente assinantes

Resumo
Sobre autores
Bibliografia
Estatísticas

Resumo

Mediator is a key factor in the regulation of expression of RNA polymerase II-transcribed genes. Recent studies have shown that Mediator acts as a coordinator of transcription activation and participates in maintaining chromatin architecture in the cell nucleus. In this review, we present current concepts on the structure and functions of Mediator.