Recombinant monoclonal antibodies for rabies post-exposure prophylaxis
- 作者: Ilina E.1, Larina M.2, Aliev T.3, Dolgikh D.1,2, Kirpichnikov M.1,2
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隶属关系:
- Faculty of Biology
- Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
- Faculty of Chemistry
- 期: 卷 83, 编号 1 (2018)
- 页面: 1-12
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151562
- DOI: https://doi.org/10.1134/S0006297918010017
- ID: 151562
如何引用文章
详细
Rabies virus is a prototypical neurotropic virus that causes one of the most dangerous zoonotic diseases in humans. Humanized or fully human monoclonal antibodies (mAb) that neutralize rabies virus would be the basis for powerful post-exposure prophylaxis of rabies in humans, having several significant benefits in comparison with human or equine rabies polyclonal immunoglobulins. The most advanced antibodies should broadly neutralize natural rabies virus isolates, bind with conserved antigenic determinants of the rabies virus glycoprotein, and show high neutralizing potency in assays in vivo. The antibodies should recognize nonoverlapping epitopes if they are used in combination. This review focuses on basic requirements for anti-rabies therapeutic antibodies. The urgency in the search for novel rabies post-exposure prophylaxis and methods of development of anti-rabies human mAb cocktail are discussed. The rabies virus structure and pathways of its penetration into the nervous system are also briefly described.
作者简介
E. Ilina
Faculty of Biology
编辑信件的主要联系方式.
Email: ekaterina.iljina.7@yandex.ru
俄罗斯联邦, Moscow, 119991
M. Larina
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina.iljina.7@yandex.ru
俄罗斯联邦, Moscow, 117997
T. Aliev
Faculty of Chemistry
Email: ekaterina.iljina.7@yandex.ru
俄罗斯联邦, Moscow, 119991
D. Dolgikh
Faculty of Biology; Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina.iljina.7@yandex.ru
俄罗斯联邦, Moscow, 119991; Moscow, 117997
M. Kirpichnikov
Faculty of Biology; Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina.iljina.7@yandex.ru
俄罗斯联邦, Moscow, 119991; Moscow, 117997
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