Recombinant monoclonal antibodies for rabies post-exposure prophylaxis
- Authors: Ilina E.N.1, Larina M.V.2, Aliev T.K.3, Dolgikh D.A.1,2, Kirpichnikov M.P.1,2
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Affiliations:
- Faculty of Biology
- Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
- Faculty of Chemistry
- Issue: Vol 83, No 1 (2018)
- Pages: 1-12
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151562
- DOI: https://doi.org/10.1134/S0006297918010017
- ID: 151562
Cite item
Abstract
Rabies virus is a prototypical neurotropic virus that causes one of the most dangerous zoonotic diseases in humans. Humanized or fully human monoclonal antibodies (mAb) that neutralize rabies virus would be the basis for powerful post-exposure prophylaxis of rabies in humans, having several significant benefits in comparison with human or equine rabies polyclonal immunoglobulins. The most advanced antibodies should broadly neutralize natural rabies virus isolates, bind with conserved antigenic determinants of the rabies virus glycoprotein, and show high neutralizing potency in assays in vivo. The antibodies should recognize nonoverlapping epitopes if they are used in combination. This review focuses on basic requirements for anti-rabies therapeutic antibodies. The urgency in the search for novel rabies post-exposure prophylaxis and methods of development of anti-rabies human mAb cocktail are discussed. The rabies virus structure and pathways of its penetration into the nervous system are also briefly described.
About the authors
E. N. Ilina
Faculty of Biology
Author for correspondence.
Email: ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 119991
M. V. Larina
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 117997
T. K. Aliev
Faculty of Chemistry
Email: ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 119991
D. A. Dolgikh
Faculty of Biology; Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 119991; Moscow, 117997
M. P. Kirpichnikov
Faculty of Biology; Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 119991; Moscow, 117997
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