Neuroprotective properties of endocannabinoids N-arachidonoyl dopamine and N-docosahexaenoyl dopamine examined in neuronal precursors derived from human pluripotent stem cells
- 作者: Novosadova E.1, Arsenyeva E.1, Manuilova E.1, Khaspekov L.2, Bobrov M.3,4, Bezuglov V.3, Illarioshkin S.2, Grivennikov I.1
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隶属关系:
- Institute of Molecular Genetics
- Research Center of Neurology
- Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
- Kulakov Research Center of Obstetrics, Gynecology, and Perinatology
- 期: 卷 82, 编号 11 (2017)
- 页面: 1367-1372
- 栏目: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151518
- DOI: https://doi.org/10.1134/S0006297917110141
- ID: 151518
如何引用文章
详细
Neuroprotective properties of endocannabinoids N-arachidonoyl dopamine (NADA) and N-docosahexaenoyl dopamine (DHDA) were examined in neuronal precursor cells differentiated from human induced pluripotent stem cells and subjected to oxidative stress. Both compounds exerted neuroprotective activity, which was enhanced by elevating the concentration of the endocannabinoids within the 0.1–10 μM range. However, both agents at 10 μM concentration showed a marked toxic effect resulting in death of ~30% of the cells. Finally, antagonists of cannabinoid receptors as well as the receptor of the TRPV1 endovanilloid system did not hamper the neuroprotective effects of these endocannabinoids.
作者简介
E. Novosadova
Institute of Molecular Genetics
编辑信件的主要联系方式.
Email: novek-img@mail.ru
俄罗斯联邦, Moscow, 123182
E. Arsenyeva
Institute of Molecular Genetics
Email: grivigan@mail.ru
俄罗斯联邦, Moscow, 123182
E. Manuilova
Institute of Molecular Genetics
Email: grivigan@mail.ru
俄罗斯联邦, Moscow, 123182
L. Khaspekov
Research Center of Neurology
Email: grivigan@mail.ru
俄罗斯联邦, Moscow, 125367
M. Bobrov
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry; Kulakov Research Center of Obstetrics, Gynecology, and Perinatology
Email: grivigan@mail.ru
俄罗斯联邦, Moscow, 117997; Moscow, 117997
V. Bezuglov
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: grivigan@mail.ru
俄罗斯联邦, Moscow, 117997
S. Illarioshkin
Research Center of Neurology
Email: grivigan@mail.ru
俄罗斯联邦, Moscow, 125367
I. Grivennikov
Institute of Molecular Genetics
编辑信件的主要联系方式.
Email: grivigan@mail.ru
俄罗斯联邦, Moscow, 123182
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