Mazes of Nrf2 regulation
- 作者: Zenkov N.1, Kozhin P.1, Chechushkov A.1, Martinovich G.2, Kandalintseva N.3, Menshchikova E.1
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隶属关系:
- Research Institute of Experimental and Clinical Medicine
- Belarusian State University
- Novosibirsk State Pedagogical University
- 期: 卷 82, 编号 5 (2017)
- 页面: 556-564
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151371
- DOI: https://doi.org/10.1134/S0006297917050030
- ID: 151371
如何引用文章
详细
Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress and is a perspective target for oxidative stress-associated diseases. Under normal conditions, Nrf2 transcriptional activity is low due to its rapid ubiquitination and degradation in the 26S proteasome, as well as through various modifications of amino acid residues of this transcription factor that regulate its transport to the nucleus and binding to DNA. Continuous activation of Nrf2 is possible due to autophagy and epigenetic regulation that may underlie the increased resistance of tumor cells to radiotherapy and chemotherapy. This review deals with the mechanisms of regulation of Nrf2 transcriptional activity and its main elements, and pharmacological approaches to activation of the Keap1/Nrf2/ARE system.
作者简介
N. Zenkov
Research Institute of Experimental and Clinical Medicine
Email: lemen@centercem.ru
俄罗斯联邦, Novosibirsk, 630117
P. Kozhin
Research Institute of Experimental and Clinical Medicine
Email: lemen@centercem.ru
俄罗斯联邦, Novosibirsk, 630117
A. Chechushkov
Research Institute of Experimental and Clinical Medicine
Email: lemen@centercem.ru
俄罗斯联邦, Novosibirsk, 630117
G. Martinovich
Belarusian State University
Email: lemen@centercem.ru
白俄罗斯, Minsk, 220030
N. Kandalintseva
Novosibirsk State Pedagogical University
Email: lemen@centercem.ru
俄罗斯联邦, Novosibirsk, 630126
E. Menshchikova
Research Institute of Experimental and Clinical Medicine
编辑信件的主要联系方式.
Email: lemen@centercem.ru
俄罗斯联邦, Novosibirsk, 630117