Mazes of Nrf2 regulation
- Authors: Zenkov N.K.1, Kozhin P.M.1, Chechushkov A.V.1, Martinovich G.G.2, Kandalintseva N.V.3, Menshchikova E.B.1
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Affiliations:
- Research Institute of Experimental and Clinical Medicine
- Belarusian State University
- Novosibirsk State Pedagogical University
- Issue: Vol 82, No 5 (2017)
- Pages: 556-564
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151371
- DOI: https://doi.org/10.1134/S0006297917050030
- ID: 151371
Cite item
Abstract
Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress and is a perspective target for oxidative stress-associated diseases. Under normal conditions, Nrf2 transcriptional activity is low due to its rapid ubiquitination and degradation in the 26S proteasome, as well as through various modifications of amino acid residues of this transcription factor that regulate its transport to the nucleus and binding to DNA. Continuous activation of Nrf2 is possible due to autophagy and epigenetic regulation that may underlie the increased resistance of tumor cells to radiotherapy and chemotherapy. This review deals with the mechanisms of regulation of Nrf2 transcriptional activity and its main elements, and pharmacological approaches to activation of the Keap1/Nrf2/ARE system.
About the authors
N. K. Zenkov
Research Institute of Experimental and Clinical Medicine
Email: lemen@centercem.ru
Russian Federation, Novosibirsk, 630117
P. M. Kozhin
Research Institute of Experimental and Clinical Medicine
Email: lemen@centercem.ru
Russian Federation, Novosibirsk, 630117
A. V. Chechushkov
Research Institute of Experimental and Clinical Medicine
Email: lemen@centercem.ru
Russian Federation, Novosibirsk, 630117
G. G. Martinovich
Belarusian State University
Email: lemen@centercem.ru
Belarus, Minsk, 220030
N. V. Kandalintseva
Novosibirsk State Pedagogical University
Email: lemen@centercem.ru
Russian Federation, Novosibirsk, 630126
E. B. Menshchikova
Research Institute of Experimental and Clinical Medicine
Author for correspondence.
Email: lemen@centercem.ru
Russian Federation, Novosibirsk, 630117