Do mitochondria have an immune system?
- 作者: Popkov V.1,2, Zorova L.3, Korvigo I.4, Silachev D.1, Jankauskas S.1, Babenko V.1,2, Pevzner I.1, Danilina T.2, Zorov S.2, Plotnikov E.1, Zorov D.1
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隶属关系:
- Belozersky Institute of Physico-Chemical Biology
- Faculty of Bioengineering and Bioinformatics
- International Laser Research Center
- Moscow Institute of Physics and Technology
- 期: 卷 81, 编号 10 (2016)
- 页面: 1229-1236
- 栏目: Hypothesis
- URL: https://journals.rcsi.science/0006-2979/article/view/151070
- DOI: https://doi.org/10.1134/S0006297916100217
- ID: 151070
如何引用文章
详细
The question if mitochondria have some kind of immune system is not trivial. The basis for raising this question is the fact that bacteria, which are progenitors of mitochondria, do have an immune system. The CRISPR system in bacteria based on the principle of RNA interference serves as an organized mechanism for destroying alien nucleic acids, primarily those of viral origin. We have shown that mitochondria are also a target for viral attacks, probably due to a related organization of genomes in these organelles and bacteria. Bioinformatic analysis performed in this study has not given a clear answer if there is a CRISPR-like immune system in mitochondria. However, this does not preclude the possibility of mitochondrial immunity that can be difficult to decipher or that is based on some principles other than those of CRISPR.
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作者简介
V. Popkov
Belozersky Institute of Physico-Chemical Biology; Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
俄罗斯联邦, Moscow, 119991; Moscow, 119991
L. Zorova
International Laser Research Center
Email: zorov@genebee.msu.su
俄罗斯联邦, Moscow, 119991
I. Korvigo
Moscow Institute of Physics and Technology
Email: zorov@genebee.msu.su
俄罗斯联邦, Dolgoprudny, 141701
D. Silachev
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
俄罗斯联邦, Moscow, 119991
S. Jankauskas
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
俄罗斯联邦, Moscow, 119991
V. Babenko
Belozersky Institute of Physico-Chemical Biology; Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
俄罗斯联邦, Moscow, 119991; Moscow, 119991
I. Pevzner
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
俄罗斯联邦, Moscow, 119991
T. Danilina
Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
俄罗斯联邦, Moscow, 119991
S. Zorov
Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
俄罗斯联邦, Moscow, 119991
E. Plotnikov
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
俄罗斯联邦, Moscow, 119991
D. Zorov
Belozersky Institute of Physico-Chemical Biology
编辑信件的主要联系方式.
Email: zorov@genebee.msu.su
俄罗斯联邦, Moscow, 119991
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