Do mitochondria have an immune system?
- Autores: Popkov V.1,2, Zorova L.3, Korvigo I.4, Silachev D.1, Jankauskas S.1, Babenko V.1,2, Pevzner I.1, Danilina T.2, Zorov S.2, Plotnikov E.1, Zorov D.1
-
Afiliações:
- Belozersky Institute of Physico-Chemical Biology
- Faculty of Bioengineering and Bioinformatics
- International Laser Research Center
- Moscow Institute of Physics and Technology
- Edição: Volume 81, Nº 10 (2016)
- Páginas: 1229-1236
- Seção: Hypothesis
- URL: https://journals.rcsi.science/0006-2979/article/view/151070
- DOI: https://doi.org/10.1134/S0006297916100217
- ID: 151070
Citar
Resumo
The question if mitochondria have some kind of immune system is not trivial. The basis for raising this question is the fact that bacteria, which are progenitors of mitochondria, do have an immune system. The CRISPR system in bacteria based on the principle of RNA interference serves as an organized mechanism for destroying alien nucleic acids, primarily those of viral origin. We have shown that mitochondria are also a target for viral attacks, probably due to a related organization of genomes in these organelles and bacteria. Bioinformatic analysis performed in this study has not given a clear answer if there is a CRISPR-like immune system in mitochondria. However, this does not preclude the possibility of mitochondrial immunity that can be difficult to decipher or that is based on some principles other than those of CRISPR.
Palavras-chave
Sobre autores
V. Popkov
Belozersky Institute of Physico-Chemical Biology; Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
Rússia, Moscow, 119991; Moscow, 119991
L. Zorova
International Laser Research Center
Email: zorov@genebee.msu.su
Rússia, Moscow, 119991
I. Korvigo
Moscow Institute of Physics and Technology
Email: zorov@genebee.msu.su
Rússia, Dolgoprudny, 141701
D. Silachev
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
Rússia, Moscow, 119991
S. Jankauskas
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
Rússia, Moscow, 119991
V. Babenko
Belozersky Institute of Physico-Chemical Biology; Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
Rússia, Moscow, 119991; Moscow, 119991
I. Pevzner
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
Rússia, Moscow, 119991
T. Danilina
Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
Rússia, Moscow, 119991
S. Zorov
Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
Rússia, Moscow, 119991
E. Plotnikov
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
Rússia, Moscow, 119991
D. Zorov
Belozersky Institute of Physico-Chemical Biology
Autor responsável pela correspondência
Email: zorov@genebee.msu.su
Rússia, Moscow, 119991
![](/img/style/loading.gif)