Do mitochondria have an immune system?
- Авторы: Popkov V.1,2, Zorova L.3, Korvigo I.4, Silachev D.1, Jankauskas S.1, Babenko V.1,2, Pevzner I.1, Danilina T.2, Zorov S.2, Plotnikov E.1, Zorov D.1
-
Учреждения:
- Belozersky Institute of Physico-Chemical Biology
- Faculty of Bioengineering and Bioinformatics
- International Laser Research Center
- Moscow Institute of Physics and Technology
- Выпуск: Том 81, № 10 (2016)
- Страницы: 1229-1236
- Раздел: Hypothesis
- URL: https://journals.rcsi.science/0006-2979/article/view/151070
- DOI: https://doi.org/10.1134/S0006297916100217
- ID: 151070
Цитировать
Аннотация
The question if mitochondria have some kind of immune system is not trivial. The basis for raising this question is the fact that bacteria, which are progenitors of mitochondria, do have an immune system. The CRISPR system in bacteria based on the principle of RNA interference serves as an organized mechanism for destroying alien nucleic acids, primarily those of viral origin. We have shown that mitochondria are also a target for viral attacks, probably due to a related organization of genomes in these organelles and bacteria. Bioinformatic analysis performed in this study has not given a clear answer if there is a CRISPR-like immune system in mitochondria. However, this does not preclude the possibility of mitochondrial immunity that can be difficult to decipher or that is based on some principles other than those of CRISPR.
Ключевые слова
Об авторах
V. Popkov
Belozersky Institute of Physico-Chemical Biology; Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
Россия, Moscow, 119991; Moscow, 119991
L. Zorova
International Laser Research Center
Email: zorov@genebee.msu.su
Россия, Moscow, 119991
I. Korvigo
Moscow Institute of Physics and Technology
Email: zorov@genebee.msu.su
Россия, Dolgoprudny, 141701
D. Silachev
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
Россия, Moscow, 119991
S. Jankauskas
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
Россия, Moscow, 119991
V. Babenko
Belozersky Institute of Physico-Chemical Biology; Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
Россия, Moscow, 119991; Moscow, 119991
I. Pevzner
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
Россия, Moscow, 119991
T. Danilina
Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
Россия, Moscow, 119991
S. Zorov
Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.su
Россия, Moscow, 119991
E. Plotnikov
Belozersky Institute of Physico-Chemical Biology
Email: zorov@genebee.msu.su
Россия, Moscow, 119991
D. Zorov
Belozersky Institute of Physico-Chemical Biology
Автор, ответственный за переписку.
Email: zorov@genebee.msu.su
Россия, Moscow, 119991