Problems of glioblastoma multiforme drug resistance
- 作者: Stavrovskaya A.1, Shushanov S.1, Rybalkina E.1
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隶属关系:
- Blokhin Russian Cancer Research Center
- 期: 卷 81, 编号 2 (2016)
- 页面: 91-100
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150768
- DOI: https://doi.org/10.1134/S0006297916020036
- ID: 150768
如何引用文章
详细
Glioblastoma multiforme (GBL) is the most common and aggressive brain neoplasm. A standard therapeutic approach for GBL involves combination therapy consisting of surgery, radiotherapy, and chemotherapy. The latter is based on temozolomide (TMZ). However, even by applying such a radical treatment strategy, the mean patient survival time is only 14.6 months. Here we review the molecular mechanisms underlying the resistance of GBL cells to TMZ including genetic and epigenetic mechanisms. Present data regarding a role for genes and proteins MGMT, IDH1/2, YB-1, MELK, MVP/LRP, MDR1 (ABCB1), and genes encoding other ABC transporters as well as Akt3 kinase in developing resistance of GBL to TMZ are discussed. Some epigenetic regulators of resistance to TMZ such as microRNA and EZH2 are reviewed.
作者简介
A. Stavrovskaya
Blokhin Russian Cancer Research Center
Email: Kate_Rybalkina@mail.ru
俄罗斯联邦, Moscow, 115478
S. Shushanov
Blokhin Russian Cancer Research Center
Email: Kate_Rybalkina@mail.ru
俄罗斯联邦, Moscow, 115478
E. Rybalkina
Blokhin Russian Cancer Research Center
编辑信件的主要联系方式.
Email: Kate_Rybalkina@mail.ru
俄罗斯联邦, Moscow, 115478
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