Problems of glioblastoma multiforme drug resistance
- Авторы: Stavrovskaya A.1, Shushanov S.1, Rybalkina E.1
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Учреждения:
- Blokhin Russian Cancer Research Center
- Выпуск: Том 81, № 2 (2016)
- Страницы: 91-100
- Раздел: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150768
- DOI: https://doi.org/10.1134/S0006297916020036
- ID: 150768
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Аннотация
Glioblastoma multiforme (GBL) is the most common and aggressive brain neoplasm. A standard therapeutic approach for GBL involves combination therapy consisting of surgery, radiotherapy, and chemotherapy. The latter is based on temozolomide (TMZ). However, even by applying such a radical treatment strategy, the mean patient survival time is only 14.6 months. Here we review the molecular mechanisms underlying the resistance of GBL cells to TMZ including genetic and epigenetic mechanisms. Present data regarding a role for genes and proteins MGMT, IDH1/2, YB-1, MELK, MVP/LRP, MDR1 (ABCB1), and genes encoding other ABC transporters as well as Akt3 kinase in developing resistance of GBL to TMZ are discussed. Some epigenetic regulators of resistance to TMZ such as microRNA and EZH2 are reviewed.
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Об авторах
A. Stavrovskaya
Blokhin Russian Cancer Research Center
Email: Kate_Rybalkina@mail.ru
Россия, Moscow, 115478
S. Shushanov
Blokhin Russian Cancer Research Center
Email: Kate_Rybalkina@mail.ru
Россия, Moscow, 115478
E. Rybalkina
Blokhin Russian Cancer Research Center
Автор, ответственный за переписку.
Email: Kate_Rybalkina@mail.ru
Россия, Moscow, 115478
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