Iron-sulfur clusters in mitochondrial metabolism: Multifaceted roles of a simple cofactor


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Iron-sulfur metabolism is essential for cellular function and is a key process in mitochondria. In this review, we focus on the structure and assembly of mitochondrial iron-sulfur clusters and their roles in various metabolic processes that occur in mitochondria. Iron-sulfur clusters are crucial in mitochondrial respiration, in which they are required for the assembly, stability, and function of respiratory complexes I, II, and III. They also serve important functions in the citric acid cycle, DNA metabolism, and apoptosis. Whereas the identification of iron-sulfur containing proteins and their roles in numerous aspects of cellular function has been a long-standing research area, that in mitochondria is comparatively recent, and it is likely that their roles within mitochondria have been only partially revealed. We review the status of the field and provide examples of other cellular iron-sulfur proteins to highlight their multifarious roles.

Sobre autores

Johnny Stiban

Department of Biology and Biochemistry

Autor responsável pela correspondência
Email: jstiban@birzeit.edu
Estado da Palestina, West Bank 627, Birzeit

Minyoung So

Department of Biochemistry and Molecular Biology and Center for Mitochondrial Science and Medicine

Email: lskaguni@msu.edu
Estados Unidos da América, East Lansing, Michigan, 48824

Laurie Kaguni

Department of Biochemistry and Molecular Biology and Center for Mitochondrial Science and Medicine

Autor responsável pela correspondência
Email: lskaguni@msu.edu
Estados Unidos da América, East Lansing, Michigan, 48824

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