Iron-sulfur clusters in mitochondrial metabolism: Multifaceted roles of a simple cofactor
- Authors: Stiban J.1, So M.2, Kaguni L.S.2
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Affiliations:
- Department of Biology and Biochemistry
- Department of Biochemistry and Molecular Biology and Center for Mitochondrial Science and Medicine
- Issue: Vol 81, No 10 (2016)
- Pages: 1066-1080
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151027
- DOI: https://doi.org/10.1134/S0006297916100059
- ID: 151027
Cite item
Abstract
Iron-sulfur metabolism is essential for cellular function and is a key process in mitochondria. In this review, we focus on the structure and assembly of mitochondrial iron-sulfur clusters and their roles in various metabolic processes that occur in mitochondria. Iron-sulfur clusters are crucial in mitochondrial respiration, in which they are required for the assembly, stability, and function of respiratory complexes I, II, and III. They also serve important functions in the citric acid cycle, DNA metabolism, and apoptosis. Whereas the identification of iron-sulfur containing proteins and their roles in numerous aspects of cellular function has been a long-standing research area, that in mitochondria is comparatively recent, and it is likely that their roles within mitochondria have been only partially revealed. We review the status of the field and provide examples of other cellular iron-sulfur proteins to highlight their multifarious roles.
About the authors
Johnny Stiban
Department of Biology and Biochemistry
Author for correspondence.
Email: jstiban@birzeit.edu
Palestinian Territory, Occupied, West Bank 627, Birzeit
Minyoung So
Department of Biochemistry and Molecular Biology and Center for Mitochondrial Science and Medicine
Email: lskaguni@msu.edu
United States, East Lansing, Michigan, 48824
Laurie S. Kaguni
Department of Biochemistry and Molecular Biology and Center for Mitochondrial Science and Medicine
Author for correspondence.
Email: lskaguni@msu.edu
United States, East Lansing, Michigan, 48824