Pseudogenes as Functionally Significant Elements of the Genome
- Autores: Kovalenko T.1, Patrushev L.1
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Afiliações:
- Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
- Edição: Volume 83, Nº 11 (2018)
- Páginas: 1332-1349
- Seção: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151752
- DOI: https://doi.org/10.1134/S0006297918110044
- ID: 151752
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Resumo
Pseudogene is a gene copy that has lost its original function. For a long time, pseudogenes have been considered as “junk DNA” that inevitably arises as a result of ongoing evolutionary process. However, experimental data obtained during recent years indicate this understanding of the nature of pseudogenes is not entirely correct, and many pseudogenes perform important genetic functions. In the review, we have addressed classification of pseudogenes, methods of their detection in the genome, and the problem of their evolutionary conservatism and prevalence among species belonging to different taxonomic groups in the light of modern data. The mechanisms of gene expression regulation by pseudogenes and the role of pseudogenes in pathogenesis of various human diseases are discussed.
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Sobre autores
T. Kovalenko
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Autor responsável pela correspondência
Email: t_kov@mail.ru
Rússia, Moscow, 117997
L. Patrushev
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: t_kov@mail.ru
Rússia, Moscow, 117997
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