Pseudogenes as Functionally Significant Elements of the Genome
- Авторлар: Kovalenko T.1, Patrushev L.1
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Мекемелер:
- Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
- Шығарылым: Том 83, № 11 (2018)
- Беттер: 1332-1349
- Бөлім: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151752
- DOI: https://doi.org/10.1134/S0006297918110044
- ID: 151752
Дәйексөз келтіру
Аннотация
Pseudogene is a gene copy that has lost its original function. For a long time, pseudogenes have been considered as “junk DNA” that inevitably arises as a result of ongoing evolutionary process. However, experimental data obtained during recent years indicate this understanding of the nature of pseudogenes is not entirely correct, and many pseudogenes perform important genetic functions. In the review, we have addressed classification of pseudogenes, methods of their detection in the genome, and the problem of their evolutionary conservatism and prevalence among species belonging to different taxonomic groups in the light of modern data. The mechanisms of gene expression regulation by pseudogenes and the role of pseudogenes in pathogenesis of various human diseases are discussed.
Негізгі сөздер
Авторлар туралы
T. Kovalenko
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Хат алмасуға жауапты Автор.
Email: t_kov@mail.ru
Ресей, Moscow, 117997
L. Patrushev
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: t_kov@mail.ru
Ресей, Moscow, 117997
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