Enviar artigo por via de e-mail Essential Light Chains of Myosin and Their Role in Functioning of the Myosin Motor
- Autores: Logvinova D.1,2, Levitsky D.1,3
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Afiliações:
- Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”
- Lomonosov Moscow State University, Faculty of Biology
- Belozersky Institute of Physico-Chemical Biology
- Edição: Volume 83, Nº 8 (2018)
- Páginas: 944-960
- Seção: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151699
- DOI: https://doi.org/10.1134/S0006297918080060
- ID: 151699
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Resumo
This review summarizes current data on the structure and functions of myosin essential light chains (ELCs) and on their role in functioning of the myosin head as a molecular motor. The data on structural and functional features of the N-terminal extension of myosin ELC from skeletal and cardiac muscles are analyzed; the role of this extension in the ATP- dependent interaction of myosin heads with actin in the molecular mechanism of muscle contraction is discussed. The data on possible interactions of the ELC N-terminal extension with the myosin head motor domain in the myosin ATPase cycle are presented, including the results of the authors’ studies that are in favor of such interactions.
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Sobre autores
D. Logvinova
Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”; Lomonosov Moscow State University, Faculty of Biology
Autor responsável pela correspondência
Email: daria_logvinova@mail.ru
Rússia, Moscow, 119071; Moscow, 119991
D. Levitsky
Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”; Belozersky Institute of Physico-Chemical Biology
Email: daria_logvinova@mail.ru
Rússia, Moscow, 119071; Moscow, 119991
