Email this article Essential Light Chains of Myosin and Their Role in Functioning of the Myosin Motor
- Authors: Logvinova D.S.1,2, Levitsky D.I.1,3
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Affiliations:
- Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”
- Lomonosov Moscow State University, Faculty of Biology
- Belozersky Institute of Physico-Chemical Biology
- Issue: Vol 83, No 8 (2018)
- Pages: 944-960
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151699
- DOI: https://doi.org/10.1134/S0006297918080060
- ID: 151699
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Abstract
This review summarizes current data on the structure and functions of myosin essential light chains (ELCs) and on their role in functioning of the myosin head as a molecular motor. The data on structural and functional features of the N-terminal extension of myosin ELC from skeletal and cardiac muscles are analyzed; the role of this extension in the ATP- dependent interaction of myosin heads with actin in the molecular mechanism of muscle contraction is discussed. The data on possible interactions of the ELC N-terminal extension with the myosin head motor domain in the myosin ATPase cycle are presented, including the results of the authors’ studies that are in favor of such interactions.
About the authors
D. S. Logvinova
Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”; Lomonosov Moscow State University, Faculty of Biology
Author for correspondence.
Email: daria_logvinova@mail.ru
Russian Federation, Moscow, 119071; Moscow, 119991
D. I. Levitsky
Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”; Belozersky Institute of Physico-Chemical Biology
Email: daria_logvinova@mail.ru
Russian Federation, Moscow, 119071; Moscow, 119991
