Components of the hepatocellular carcinoma microenvironment and their role in tumor progression
- Авторлар: Novikova M.1, Khromova N.1, Kopnin P.1
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Мекемелер:
- Blokhin Russian Cancer Research Center
- Шығарылым: Том 82, № 8 (2017)
- Беттер: 861-873
- Бөлім: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151444
- DOI: https://doi.org/10.1134/S0006297917080016
- ID: 151444
Дәйексөз келтіру
Аннотация
This review summarizes recently published data on the mechanisms of tumor cell interaction with the tumor microenvironment. Tumor stroma influences the processes of hepatocarcinogenesis, epithelial-to-mesenchymal transition, invasion, and metastasis. The tumor microenvironment includes both cellular and noncellular components. Main cellular components of hepatocellular carcinoma (HCC) stroma are tumor-associated fibroblasts, hepatic stellate cells, immune cells, and endothelial cells that produce extracellular components of tumor microenvironment such as extracellular matrix, various proteins, proteolytic enzymes, growth factors, and cytokines. The noncellular components of the stroma modulate signaling pathways in tumor cells and stimulate invasion and metastasis. The tumor microenvironment composition and organization can serve as prognostic factors in HCC pathogenesis. Current approaches in HCC targeted therapy are aimed at creating efficient strategies for interrupting tumor interactions with the stroma. Recent data on the composition and role of the microenvironment in HCC pathogenesis, as well as new developments in antitumor drug design are discussed.
Авторлар туралы
M. Novikova
Blokhin Russian Cancer Research Center
Email: pbkopnin@mail.ru
Ресей, Moscow, 115478
N. Khromova
Blokhin Russian Cancer Research Center
Email: pbkopnin@mail.ru
Ресей, Moscow, 115478
P. Kopnin
Blokhin Russian Cancer Research Center
Хат алмасуға жауапты Автор.
Email: pbkopnin@mail.ru
Ресей, Moscow, 115478