Analysis of Insulin Analogs and the Strategy of Their Further Development
- Authors: Selivanova O.M.1, Grishin S.Y.1,2, Glyakina A.V.1,3, Sadgyan A.S.4, Ushakova N.I.4, Galzitskaya O.V.1
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Affiliations:
- Institute of Protein Research
- Lomonosov Moscow State University
- Institute of Mathematical Problems of Biology, Keldysh Institute of Applied Mathematics
- Joint-Stock Scientific Production Association Bioran
- Issue: Vol 83, No 1 (2018): Suppl
- Pages: S146-S162
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151588
- DOI: https://doi.org/10.1134/S0006297918140122
- ID: 151588
Cite item
Abstract
We analyzed the structural properties of the peptide hormone insulin and described the mechanism of its physiological action, as well as effects of insulin in type 1 and 2 diabetes. Recently published data on the development of novel insulin preparations based on combining molecular design and genetic engineering approaches are presented. New strategies for creation of long-acting insulin analogs, the mechanisms of functioning of these analogs and their structure are discussed. Side effects of insulin preparations are described, including amyloidogenesis and possible mitogenic effect. The pathways for development of novel insulin analogs are outlined with regard to the current requirements for therapeutic preparations due to the wider occurrence of diabetes of both types.
About the authors
O. M. Selivanova
Institute of Protein Research
Email: ogalzit@vega.protres.ru
Russian Federation, Pushchino, Moscow Region, 142290
S. Yu. Grishin
Institute of Protein Research; Lomonosov Moscow State University
Email: ogalzit@vega.protres.ru
Russian Federation, Pushchino, Moscow Region, 142290; Moscow, 119991
A. V. Glyakina
Institute of Protein Research; Institute of Mathematical Problems of Biology, Keldysh Institute of Applied Mathematics
Email: ogalzit@vega.protres.ru
Russian Federation, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
A. S. Sadgyan
Joint-Stock Scientific Production Association Bioran
Email: ogalzit@vega.protres.ru
Russian Federation, Moscow, 119261
N. I. Ushakova
Joint-Stock Scientific Production Association Bioran
Email: ogalzit@vega.protres.ru
Russian Federation, Moscow, 119261
O. V. Galzitskaya
Institute of Protein Research
Author for correspondence.
Email: ogalzit@vega.protres.ru
Russian Federation, Pushchino, Moscow Region, 142290
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