Nucleolar methyltransferase fibrillarin: Evolution of structure and functions

M. Y. Shubina; Y. R. Musinova; E. V. Sheval

doi:10.1134/S0006297916090030

Nucleolar methyltransferase fibrillarin: Evolution of structure and functions

Authors: Shubina M.Y.¹, Musinova Y.R.¹, Sheval E.V.¹
Affiliations:
1. Lomonosov Moscow State University
Issue: Vol 81, No 9 (2016)
Pages: 941-950
Section: Review
URL: https://journals.rcsi.science/0006-2979/article/view/150997
DOI: https://doi.org/10.1134/S0006297916090030
ID: 150997

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Abstract

Fibrillarin is one of the most studied nucleolar proteins. Its main functions are methylation and processing of pre-rRNA. Fibrillarin is a highly conserved protein; however, in the course of evolution from archaea to eukaryotes, it acquired an additional N-terminal glycine and arginine-rich (GAR) domain. In this review, we discuss the evolution of fibrillarin structure and its relation to the functions of the protein in prokaryotes and eukaryotes.