Email this article Inorganic Polyphosphate and Cancer
- Authors: Kulakovskaya E.V.1, Zemskova M.Y.1,2, Kulakovskaya T.V.1
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Affiliations:
- Skryabin Institute of Biochemistry and Physiology of Microorganisms
- Moscow State Regional University
- Issue: Vol 83, No 8 (2018)
- Pages: 961-968
- Section: Mini-Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151701
- DOI: https://doi.org/10.1134/S0006297918080072
- ID: 151701
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Abstract
This review presents data on the relationship between inorganic polyphosphate metabolism and carcinogenesis including participation of polyphosphates in the regulation of activity of mTOR and other proteins involved in carcinogenesis, the role of h-prune protein (human polyphosphatase) in cell migration and metastasis formation, the prospects for using polyphosphates and inhibitors of polyphosphate metabolism enzymes as agents for controlling cell proliferation and migration.
Keywords
About the authors
E. V. Kulakovskaya
Skryabin Institute of Biochemistry and Physiology of Microorganisms
Email: alla@ibpm.pushchino.ru
Russian Federation, Pushchino, Moscow Region, 142290
M. Yu. Zemskova
Skryabin Institute of Biochemistry and Physiology of Microorganisms; Moscow State Regional University
Email: alla@ibpm.pushchino.ru
Russian Federation, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
T. V. Kulakovskaya
Skryabin Institute of Biochemistry and Physiology of Microorganisms
Author for correspondence.
Email: alla@ibpm.pushchino.ru
Russian Federation, Pushchino, Moscow Region, 142290
