Email this article PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer
- Authors: Vinogradova T.V.1, Sverdlov E.D.1
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Affiliations:
- Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
- Issue: Vol 82, No 8 (2017)
- Pages: 887-893
- Section: Mini-Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151446
- DOI: https://doi.org/10.1134/S000629791708003X
- ID: 151446
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Abstract
Multifunctional activity of the PDX1 gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits various functional activities in this organ both during embryonic development and during induction and progression of pancreatic cancer. Hence, PDX1 belongs to the family of master regulators with multiple and often antagonistic functions.
About the authors
T. V. Vinogradova
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Author for correspondence.
Email: vintv56@gmail.com
Russian Federation, Moscow, 117997
E. D. Sverdlov
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: vintv56@gmail.com
Russian Federation, Moscow, 117997
