Design, synthesis, and some aspects of the biological activity of mitochondria-targeted antioxidants

Abstract

This review summarizes for the first time data on the design and synthesis of biologically active compounds of a new generation–mitochondria-targeted antioxidants, which are natural (or synthetic) p-benzoquinones conjugated via a lipophilic linker with (triphenyl)phosphonium or ammonium cations with delocalized charge. It also describes the synthesis of mitochondria-targeted antioxidants – uncouplers of oxidative phosphorylation – based on fluorescent dyes.