Design, synthesis, and some aspects of the biological activity of mitochondria-targeted antioxidants
- Авторы: Korshunova G.1, Shishkina A.1, Skulachev M.1
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Учреждения:
- Belozersky Institute of Physico-Chemical Biology
- Выпуск: Том 82, № 7 (2017)
- Страницы: 760-777
- Раздел: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151425
- DOI: https://doi.org/10.1134/S0006297917070021
- ID: 151425
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Аннотация
This review summarizes for the first time data on the design and synthesis of biologically active compounds of a new generation–mitochondria-targeted antioxidants, which are natural (or synthetic) p-benzoquinones conjugated via a lipophilic linker with (triphenyl)phosphonium or ammonium cations with delocalized charge. It also describes the synthesis of mitochondria-targeted antioxidants – uncouplers of oxidative phosphorylation – based on fluorescent dyes.
Об авторах
G. Korshunova
Belozersky Institute of Physico-Chemical Biology
Автор, ответственный за переписку.
Email: korsh@genebee.msu.ru
Россия, Moscow, 119991
A. Shishkina
Belozersky Institute of Physico-Chemical Biology
Email: korsh@genebee.msu.ru
Россия, Moscow, 119991
M. Skulachev
Belozersky Institute of Physico-Chemical Biology
Email: korsh@genebee.msu.ru
Россия, Moscow, 119991