The role of cytokines in the development of atherosclerosis


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Abstract

Atherosclerosis contributes to the development of many cardiovascular diseases, which remain the leading cause of death in developed countries. Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries. It is caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a key factor at all stages of atherosclerosis progression. Cells involved in pathogenesis of atherosclerosis were shown to be activated by soluble factors, cytokines, that strongly influence the disease development. Pro-inflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. In this review, we discuss the latest findings on the role of cytokines in the development and progression of atherosclerosis.

About the authors

A. R. Fatkhullina

Fox Chase Cancer Center

Email: Ekaterina.Koltsova@fccc.edu
United States, 333 Cottman Avenue, Philadelphia, PA

I. O. Peshkova

Fox Chase Cancer Center

Email: Ekaterina.Koltsova@fccc.edu
United States, 333 Cottman Avenue, Philadelphia, PA

E. K. Koltsova

Fox Chase Cancer Center

Author for correspondence.
Email: Ekaterina.Koltsova@fccc.edu
United States, 333 Cottman Avenue, Philadelphia, PA


Copyright (c) 2016 Pleiades Publishing, Ltd.

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