Tumor necrosis factor and lymphotoxin in regulation of intestinal inflammation
- Authors: Gubernatorova E.O.1, Tumanov A.V.1,2
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Affiliations:
- Institute of Molecular Biology
- Department of Microbiology, Immunology, and Molecular Genetics
- Issue: Vol 81, No 11 (2016)
- Pages: 1309-1325
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151091
- DOI: https://doi.org/10.1134/S0006297916110092
- ID: 151091
Cite item
Abstract
Ulcerative colitis and Crohn’s disease are the major forms of inflammatory bowel disease. Cytokines of the tumor necrosis factor (TNF) family play an important role in the regulation of intestinal inflammation. In this review, we discuss the function of key cytokines of this family–TNF and lymphotoxin (LT)–in mucosal healing, IgA production, and in control of innate lymphoid cells (ILCs), novel regulators of mucosal homeostasis in the gut. TNF plays a central role in the pathogenesis of inflammatory bowel diseases (IBD). LT regulates group 3 of ILCs and IL-22 production and protects the epithelium against damage by chemicals and mucosal bacterial pathogens. In addition, we discuss major mouse models employed to study the mechanism of intestinal inflammation, their advantages and limitations, as well as application of TNF blockers in the therapy for IBD.
About the authors
E. O. Gubernatorova
Institute of Molecular Biology
Email: tumanov@uthscsa.edu
Russian Federation, Moscow, 119991
A. V. Tumanov
Institute of Molecular Biology; Department of Microbiology, Immunology, and Molecular Genetics
Author for correspondence.
Email: tumanov@uthscsa.edu
Russian Federation, Moscow, 119991; San Antonio, TX, 78229