Tumor necrosis factor and lymphotoxin in regulation of intestinal inflammation
- 作者: Gubernatorova E.1, Tumanov A.1,2
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隶属关系:
- Institute of Molecular Biology
- Department of Microbiology, Immunology, and Molecular Genetics
- 期: 卷 81, 编号 11 (2016)
- 页面: 1309-1325
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151091
- DOI: https://doi.org/10.1134/S0006297916110092
- ID: 151091
如何引用文章
详细
Ulcerative colitis and Crohn’s disease are the major forms of inflammatory bowel disease. Cytokines of the tumor necrosis factor (TNF) family play an important role in the regulation of intestinal inflammation. In this review, we discuss the function of key cytokines of this family–TNF and lymphotoxin (LT)–in mucosal healing, IgA production, and in control of innate lymphoid cells (ILCs), novel regulators of mucosal homeostasis in the gut. TNF plays a central role in the pathogenesis of inflammatory bowel diseases (IBD). LT regulates group 3 of ILCs and IL-22 production and protects the epithelium against damage by chemicals and mucosal bacterial pathogens. In addition, we discuss major mouse models employed to study the mechanism of intestinal inflammation, their advantages and limitations, as well as application of TNF blockers in the therapy for IBD.
作者简介
E. Gubernatorova
Institute of Molecular Biology
Email: tumanov@uthscsa.edu
俄罗斯联邦, Moscow, 119991
A. Tumanov
Institute of Molecular Biology; Department of Microbiology, Immunology, and Molecular Genetics
编辑信件的主要联系方式.
Email: tumanov@uthscsa.edu
俄罗斯联邦, Moscow, 119991; San Antonio, TX, 78229