Biogenesis of micronuclei

O. P. Kisurina-Evgenieva; O. I. Sutiagina; G. E. Onishchenko

doi:10.1134/S0006297916050035

Biogenesis of micronuclei

Authors: Kisurina-Evgenieva O.P.¹, Sutiagina O.I.¹, Onishchenko G.E.¹
Affiliations:
1. Lomonosov Moscow State University
Issue: Vol 81, No 5 (2016)
Pages: 453-464
Section: Reviews
URL: https://journals.rcsi.science/0006-2979/article/view/150869
DOI: https://doi.org/10.1134/S0006297916050035
ID: 150869

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Abstract

The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by the chromosomal material localized inside these cell structures.