Email this article VapC toxin inhibition as a method for prevention of the formation of resting forms of mycobacteria
- Authors: Demidenok O.I.1, Shumkov M.S.2, Goncharenko A.V.3
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Affiliations:
- Quintiles Transnational Inc.
- Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”
- Moscow State University
- Issue: Vol 52, No 6 (2016)
- Pages: 589-592
- Section: Article
- URL: https://journals.rcsi.science/0003-6838/article/view/152058
- DOI: https://doi.org/10.1134/S0003683816060041
- ID: 152058
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Abstract
It has been shown that inactivation of the VapC toxin from the VapВС toxin-antitoxin system prevents mycobacterial cells from transitioning to an ovoid state that meets the criteria of dormancy. The results indicate a potential target for medicines that prevent the development of latent tuberculosis infection and provide a basis to obtain bacterial cells for the testing of compounds that are active towards dormant forms of mycobacteria.
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About the authors
O. I. Demidenok
Quintiles Transnational Inc.
Email: pylaevanna@gmail.com
Russian Federation, Moscow, 125167
M. S. Shumkov
Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”
Email: pylaevanna@gmail.com
Russian Federation, Moscow, 119071
A. V. Goncharenko
Moscow State University
Author for correspondence.
Email: pylaevanna@gmail.com
Russian Federation, Moscow, 119234
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