Отправить статью по E-mail VapC toxin inhibition as a method for prevention of the formation of resting forms of mycobacteria
- Авторы: Demidenok O.I.1, Shumkov M.S.2, Goncharenko A.V.3
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Учреждения:
- Quintiles Transnational Inc.
- Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”
- Moscow State University
- Выпуск: Том 52, № 6 (2016)
- Страницы: 589-592
- Раздел: Article
- URL: https://journals.rcsi.science/0003-6838/article/view/152058
- DOI: https://doi.org/10.1134/S0003683816060041
- ID: 152058
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Аннотация
It has been shown that inactivation of the VapC toxin from the VapВС toxin-antitoxin system prevents mycobacterial cells from transitioning to an ovoid state that meets the criteria of dormancy. The results indicate a potential target for medicines that prevent the development of latent tuberculosis infection and provide a basis to obtain bacterial cells for the testing of compounds that are active towards dormant forms of mycobacteria.
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Об авторах
O. Demidenok
Quintiles Transnational Inc.
Email: pylaevanna@gmail.com
Россия, Moscow, 125167
M. Shumkov
Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”
Email: pylaevanna@gmail.com
Россия, Moscow, 119071
A. Goncharenko
Moscow State University
Автор, ответственный за переписку.
Email: pylaevanna@gmail.com
Россия, Moscow, 119234
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