Prognostic value of risk factors for different clinical presentations of upper gastrointestinal tract diseases in military personnel
- 作者: Ushaeva L.A.1,2, Zavyalov D.V.2, Shubin L.B.2, Staroverov I.N.2
-
隶属关系:
- 2 Military Clinical Hospital of the Russian Guard
- Yaroslavl State Medical University
- 期: 卷 17, 编号 3 (2025)
- 页面: 78-88
- 栏目: Original study article
- URL: https://journals.rcsi.science/vszgmu/article/view/353800
- DOI: https://doi.org/10.17816/mechnikov637290
- EDN: https://elibrary.ru/VADZMF
- ID: 353800
如何引用文章
详细
BACKGROUND: The medical and social significance of upper gastrointestinal tract diseases is determined by their high prevalence and annual increase in morbidity. Military personnel have specific risk factors for the development of these pathologies that have not previously been studied in terms of their prognostic significance.
AIM: Тo assess the role of various risk factors in the development of uncomplicated and complicated upper gastrointestinal tract pathology in military personnel participating and not participating in combat operations.
METHODS: From February 2022 to December 2023, 256 military personnel aged 21 to 65 years with various mild surgical and therapeutic comorbidities and a significant gastrointestinal history were examined. All patients underwent esophagogastroduodenoscopy with testing for Helicobacter pylori. The analysis of the prevalence of gastrointestinal tract pathology was conducted in contingency tables based on morbidity data. The epidemiological significance of risk factors was evaluated by the attributable fraction (etiologic fraction), population attributable fraction, and attributable risk.
RESULTS: The main group, which included military personnel participating in combat operations, consisted of 118 individuals, while the control group, which did not participate in combat operations, comprised 138. The prevalence of upper gastrointestinal tract pathology in combatants was characterized by acute erosive and ulcerativevlesions of the mucous membrane of the esophagus, stomach, and duodenum as well as chronic duodenal ulcers, which were observed primarily in career officers — 93 cases (79%) — and by delayed complications in contract servicemen (5%), manifested as gastrointestinal bleeding. in the group not participating in hostilities, the main findings were uncomplicated duodenal ulcer and acute erosions (29%). Assessment of the significance of risk factors using the attributable fraction (etiologic fraction) and population attributable fraction, in the combatant group revealed a predominance of modifiable risk factors over non-modifiable ones, with ratios of 1.6 and 2.1, respectively.
CONCLUSION: The assessment of the role of various risks in the development of the studied upper gastrointestinal tract pathology in military personnel demonstrated the absence of dependence on the established traditional factors, with a predominance of modifiable risk factors (55.6%) due to their high prevalence. This finding has prognostic significance, since even a minor reduction in the prevalence of modifiable risk factors could lead to a significant population-level effect — a decrease in upper gastrointestinal tract diseases among military personnel.
作者简介
Ludmila Ushaeva
2 Military Clinical Hospital of the Russian Guard; Yaroslavl State Medical University
编辑信件的主要联系方式.
Email: analitika2301@mail.ru
ORCID iD: 0009-0007-6037-8960
SPIN 代码: 7169-8706
MD, Cand. Sci. (Medicine)
俄罗斯联邦, Pyatigorsk; YaroslavlDmitry Zavyalov
Yaroslavl State Medical University
Email: zavialoff@mail.ru
ORCID iD: 0000-0002-9173-6878
SPIN 代码: 8048-7985
MD, Dr. Sci. (Medicine), Assistant Professor
俄罗斯联邦, YaroslavlLeonid Shubin
Yaroslavl State Medical University
Email: LBSH@yandex.ru
ORCID iD: 0000-0003-4562-7731
SPIN 代码: 8021-7289
MD, Cand. Sci. (Medicine), Assistant Professor
俄罗斯联邦, YaroslavlIlya Staroverov
Yaroslavl State Medical University
Email: istaroverov@mail.ru
ORCID iD: 0000-0001-9855-9467
SPIN 代码: 8011-7176
MD, Dr. Sci. (Medicine), Professor
俄罗斯联邦, Yaroslavl参考
- Kotova EG, Aleksandrova GA, Kobyakova OS, et al. General morbidity of the adult population of Russia in 2021: statistical materials. Part IV. Moscow; 2022. 164 р. (In Russ.) doi: 10.21045/978-5-94116-074-7-2022 EDN: DVUUZB
- Ermolaeva AD. Priority areas for optimizing pharmaceutical care for gastroenterological patients [dissertation abstract]. Moscow; 2019. 24 p. (In Russ.)
- Nozhkina NV, Zaripova TV, Bessonova EN. Modern medical and social aspects of mortality from diseases of the digestive system. Public health and life environment – PHLE. 2018;(12(309)):47–52. doi: 10.35627/2219-5238/2018-309-12-47-52 EDN: YQGXUD
- Deev IA, Kobyakova OS, Starodubov VI, et al. Morbidity of the entire population of Russia in 2023. Statistical materials. Part II. Moscow: Russian Research Institute of Health; 2024. 154 p. (In Russ.) doi: 10.21045/978-5-94116-160-7-2024
- World Health statistic 2014. Part 1. Health–related Millennium Goals. WHO. 2014. P. 11–34.
- Alekseenko SN, Drobot EV. Disease prevention: a textbook for students of higher educational institutions. Moscow: Izd. dom Akad. estestvoznaniya; 2015. 449 p. (In Russ.)
- Deynega VI, Fadeev AV, Kruchinina NE, Kruchinin EZ. The comparison of some factors of pathogenesis of chronic gastroduodenetic pathology in service men from different professional groups. Military Medical Journal. 2006;327(4):29–30. EDN: HTOMCF
- Xie X, Ren K, Zhou Z, et al. The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study. BMC Gastroenterol. 2022;22(1):58. doi: 10.1186/s12876-022-02130-2
- Baranovsky AYu, Nazarenko LI. Unfavorable variants of the course of peptic ulcer disease (study guide). Saint Petersburg: Dialekt; 2006. 144 p. (In Russ.)
- Khasanov AG, Sufiyarov RR, Fayazov RR, et al. A comparative analysis of the treatment of patients with perforated gastric and duodenal ulcers. International Research Journal. 2021;9(111):74–78. doi: 10.23670/IRJ.2021.9.111.047 EDN: TVCZMP
- Valeev MV. Optimization of methods for diagnostics and treatment of gastroduodenal bleeding [dissertation abstract]. Ufa; 2022. 23 р. (In Russ.)
- Ivashkin VT, Lapina TL, Maev IV, et al. Clinical practice guidelines of Russian gastroenterological association, scientific society for the clinical study of human microbiome, Russian society for the prevention of non-communicable diseases, interregional association for clinical microbiology and antimicrobial chemotherapy for H. pylori diagnostics and treatment in adults. Russian Journal of Gastroenterology, Hepatology, Proctology. 2022;32(6):72–93. doi: 10.22416/1382-4376-2022-32-6-72-93 EDN: QRQFTQ
- Veijola LI, Oksanen AM, Sipponen PI, Rautelin HI. Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection. World J Gastroenterol. 2010;16(1):83–88. doi: 10.3748/wjg.v16.i1.83
- Mendes D, Alves C, Batel-Marques F. Number needed to treat (NNT) in clinical literature: an appraisal. BMC Med. 2017;15(1):112. doi: 10.1186/s12916-017-0875-8
- Harari G. Confidence interval or p-value-similarities and differences between two important methods of statistical inference of quantitative studies. Harefuah. 2014;153(1):48–51.
- Wagner C, Gulácsi L, Takacs E, Outinen M. The implementation of quality management systems in hospitals: a comparison between three countries. BMC Health Serv Res. 2006;6:50. doi: 10.1186/1472-6963-6-50
- Vlasov VV, Rebrova OYu. Criteria for population efficacy of medical technologies. Medical technologies. Evaluation and choice. 2012;3(9):33–41. EDN: PXJDFJ
- Artyukhov IP, Sul’din SA, Protasova NP. Methodological approaches to assessing population health risk factors. Siberian Medical Review. 2012;78(6):80–85. (In Russ.) EDN: PUMKCP
- Morozov SV, Dolgikh VT, Reis AB. Prediction of the course of acute pancreatitis. Sibirskii meditsinskii zhurnal (Irkutsk). 2010;96(5):11–15. EDN: NCGOVX
- Yarovoy SK, Misyakova OA, Gurbanov ShSh, et al. Antiulcer prevention in urological practice. Experimental and clinical gastroenterology. 2013;(5):53–61. EDN: SBEPLF
- Leonova MV. Patient-reported outcomes in clinical studies. Good clinical practice. 2016;(2):38–45. EDN: WWUSGL
- Marchenko AA. Acute erosive and ulcerative lesions of the upper gastrointestinal tract in patients of the purulent surgery department [dissertation]. Samara; 2017. 157 p. (In Russ.)
- Polyantsev AA, Frolov DV, Linchenko AM, et al. Incidence of peptic ulcers accompanied by gastrointestinal bleeding after surgery for critical lower limb ischemia. Pirogov Russian Journal of Surgery. 2021;(7):57–64. doi: 10.17116/hirurgia202107157 EDN: AZOOHB
- Bolkiseva PS, Fazylzyanova AR, Yamshchikova TV, et al. Identification of risk factors for the occurrence of digestive system diseases. Modern science. 2020;12(2):48–50. (In Russ.) EDN: LCKOGK
- Eganyan RA, Kushunina DV, Kalinina AM. The relevance and efficiency of early detection of digestive diseases during screening of the adult population of Russia. Preventive medicine. 2017;20(3):22–27. doi: 10.17116/profmed201720322-27 EDN: ZFLMXD
- Lizunov YuV, Erofeev VG. Possible risk factors for the health of serviceman in the context of local armed conflicts. Bulletin of the Russian Military Medical Academy. 2018;S1:102–104. EDN: GYUUGV
- Kartashov IG. Living conditions of contract servicemen as a health factor. Sotsiologicheskie issledovaniya. 2008;2(286):118–122. EDN: IPWMJN
补充文件

