Effect of thiazolidinediones on dislipidemia in patients with metabolic syndrome depending on the gene PPAR-gamma rs1801282 polymorphism

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Background. To evaluate the effect of thiazolidinediones on lipid spectrum of blood in patients with metabolic syndrome depending on gene polymorphism rs1801282.

Materials and methods. The study included 109 patients with newly diagnosed metabolic syndrome. All subjects in the study underwent general clinical, laboratory methods, presence of polymorphism rs1801282 of the PPAR-gamma gene was also determined. All patients were recommended to keep a diet, increase physical activity and receiving pioglitazone 30 mg per day for the period of 3 months.

Results.During therapy with pioglitazone it was noted that the degree of reduction of triglycerides was more pronounced in patients with IGT carrying rs1801282 -1.2 (-1.7; -1.1) versus -0.2 (-0.4; 0.0) in patients with wild genotype (p < 0.001) as well as in patients with type 2 diabetes, carries of polymorphic allele -1.3 (-1.6; -1.2) versus -0.2 (-0.3; 0.0) in patients with wild genotype (p < 0.001).

Conclusion. As a result of administering pioglitazone, an improvement in the lipid spectrum of the examined patients was noted. The maximum degree of reduction of triglycerides was observed in patients carrying rs1801282 polymorphic allele compared with the wild genotype.

作者简介

Tatyana Eremenko

North-Western State Medical University named after I.I. Mechnikov

编辑信件的主要联系方式.
Email: eremenkotanja2007@rambler.ru
ORCID iD: 0000-0002-2279-6324
SPIN 代码: 4499-4789

assistant of the department of endocrinology named after V.G.Baranov

俄罗斯联邦, 41, Kirochnaya street, Saint-Petersburg, 191015

Svetlana Kotova

North-Western State Medical University named after I.I. Mechnikov

Email: Svetlana.Kotova@szgmu.ru
SPIN 代码: 9568-4655
Scopus 作者 ID: 466298

professor of the department of endocrinology named after V.G.Baranov

俄罗斯联邦, 41, Kirochnaya street, Saint-Petersburg, 191015

Natalya Vorokhobina

North-Western State Medical University named after I.I. Mechnikov

Email: natvorokh@mail.ru
SPIN 代码: 4062-6409
Scopus 作者 ID: 291621

professor of the department of endocrinology named after V.G.Baranov

俄罗斯联邦, 41, Kirochnaya street, Saint-Petersburg, 191015

Nikolay Matsievskiy

North-Western State Medical University named after I.I. Mechnikov

Email: nicomedicus@mail.ru
ORCID iD: 0000-0003-4486-4778
SPIN 代码: 7884-5099
Researcher ID: 761194

assistant professor of the department of endocrinology named after V.G.Baranov

俄罗斯联邦, 41, Kirochnaya street, Saint-Petersburg, 191015

Irina Matezius

North-Western State Medical University named after I.I. Mechnikov

Email: Irina.Matesius@szgmu.ru
SPIN 代码: 7421-1610

assistant professor of the department of endocrinology named after V.G.Baranov

俄罗斯联邦, 41, Kirochnaya street, Saint-Petersburg, 191015

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版权所有 © Eremenko T.V., Kotova S.M., Vorokhobina N.V., Matsievskiy N.A., Matezius I.Y., 2019

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