Efficacy and renal safety of Meloxicam in patients with degenerative disk disease: Results of the “Moment” scientific programm

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Purpose of the study was to evaluate the short-term efficacy and renal safety of meloxicam in patients with low back pain due to degenerative disk disease.

Materials and methods. The study included 34 patients with low back pain who were receiving Meloxicam (in the form of rectal suppositories) in a dose of 15 mg per day for the period or 6 days and 20 healthy individuals who did not receive NSAIDs last year. We assessed the efficacy of the drug and renal safety (markers of kidney damage) over time.

Results. The mean GFR in patients with degenerative disk disease was 68.5 (57.0; 83.0) ml/min/1.73 m2, in healthy individuals, the mean GFR was 88.4 (72.5; 99.5) ml/min/1.73 m2 (p = 0.0021); the urine albumin/creatinine ratio in patients with degenerative disk disease of the spine was 35.9 (20.9; 45.0) mg/g, in control group — 18.9 (17.3; 25.0) mg/g (p = 0.0005); in patients high degree of microglobulinuria was established (94.0 (68.9, 137.1) mg/g) compared with the healthy individuals (12.5 (10.9; 13.2) mg/g), p = 0.0000. After the course of treatment, the patients revealed a reduction in the pain syndrome (p < 0.01). Moreover, there was no deterioration in renal function and an increase in markers of kidney damage (p ≥ 0.05).

Conclusions. Meloxicam is an effective drug for reducing the intensity of the low back pain in patients with degenerative disk disease. Its administration is relatively safe in terms of development of nephrotoxicity in a short term perspective.

作者简介

Dillara Bichurina

Saratov State Medical University named after V.I. Razumovsky

Email: ubp1976@list.ru
ORCID iD: 0000-0003-3500-7256
http://www.researcherid.com/rid/F-6020-2013

post-graduate student, Hospital Therapy Department of Saratov State Medical University n.a. V. I. Razumovskyy Russian Ministry of Health.

俄罗斯联邦, 112, Bolshaya Kazachia street, 410012

Inna Gaydukova

North-Western State Medical University named after I.I. Mechnikov

编辑信件的主要联系方式.
Email: ubp1976@list.ru
ORCID iD: 0000-0003-3500-7256
SPIN 代码: 3083-7996
Scopus 作者 ID: 55237525900
Researcher ID: http://www.researcherid.com/rid/F-6020-2013
http://www.researcherid.com/rid/F-6020-2013

MD, PhD, Professor of the Department of Therapy and Rheumatology n.a. E. E. Eyhvald

俄罗斯联邦, 41, Kirochnaya street, Saint-Petersburg, 191015

Andrey Rebrov

Saratov State Medical University named after V.I. Razumovsky

Email: andreyrebrov@yandex.ru

MD, PhD, Professor, Head of Hospital Therapy Department 

俄罗斯联邦, 112, Bolshaya Kazachia street, 410012

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