Influence of risk factors for the development of cardiovascular diseases on the parameters of arterial stiffness in patients with arterial hypertension and atherosclerosis of different degrees of severity

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

BACKGROUND: Arterial hypertension is widespread in the population, leads to the development of arteriosclerosis and increase of arterial stiffness, and is the main non-lipid risk factor of atherosclerosis development. Multiple studies have shown that increase of arterial stiffness is an independent risk factor for the development of cardiovascular events. However, the influence of traditional cardiovascular risk factors on arterial stiffness in arterial hypertension and atherosclerotic process of different degrees of severity has not been sufficiently studied.

AIM: To assess the influence of traditional risk factors on the parameters of arterial stiffness in patients with arterial hypertension (AH) and atherosclerotic process of varying degrees of severity.

MATERIALS AND METHODS: 133 subjects with AH have been divided into 3 groups depending on the severity of the atherosclerotic process. The control group included 33 individuals without known cardiovascular diseases. All the participants have undergone a standard clinical and laboratory examination, 24hr blood pressure monitoring with assessment of arterial stiffness (AS) parameters. The influence of risk factors on AS parameters has been analyzed for all the participants and separately by groups.

RESULTS: In the AH patients, an increase in the arterial stiffness index (ASI) is associated with an older age and an increase in systolic blood pressure (SBP); an increase in the augmentation index (AIx75) is associated with age; SBP in higher in women. Pulse wave velocity in the aorta (PWVao) is most associated with age, smoking, and family history in patients with hypertension and subclinical atherosclerosis. An increase in AIx75 is associated with an older age and is higher in women, while ASI has a positive relationship with age and SBP. In patients with hypertension and coronary artery disease, there is a positive correlation between male body mass index and PWVao. The increase in ASI in this group is associated with female gender, SBP and age. In individuals without hypertension and signs of atherosclerosis with a family history of CVD, PWVao values are higher than in similar individuals without a family history of CVD.

CONCLUSIONS: In the group of all the participants, female gender, smoking, an older age, SBP, and body mass index are associated with increased AS parameters. The association between risk factors and parameters of arterial stiffness has peculiarities in patients with hypertension with varying degrees of severity of the atherosclerotic process.

About the authors

Sergey A. Sayganov

North-Western State Medical University named after I.I. Mechnikov

Email: sergey.sayganov@szgmu.ru
ORCID iD: 0000-0001-8325-1937
SPIN-code: 2174-6400

MD, Dr. Sci. (Med.), Professor

Russian Federation, 47, Piskarevsky Ave., Saint Petersburg, 195067

Victoria E. Gumerova

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: vvoron1@yahoo.com
ORCID iD: 0000-0003-2805-3748
SPIN-code: 9872-4799
ResearcherId: ABG-7675-2020
Russian Federation, 47, Piskarevsky Ave., Saint Petersburg, 195067

Veronika V. Gomonova

North-Western State Medical University named after I.I. Mechnikov

Email: Veronika.Gomonova@szgmu.ru
ORCID iD: 0000-0002-9816-9896
SPIN-code: 6763-2979
Russian Federation, 47, Piskarevsky Ave., Saint Petersburg, 195067

References

  1. Benjamin EJ, Virani SS, Callaway CW, et al. Heart disease and stroke statistics-2018 update: a report from the american heart association. Circulation. 2018;137(12):67–492. doi: 10.1161/CIR.0000000000000558
  2. Ganelina IE, Lipovetsky BM, Tchurina SK, et al. Ateroskleroz venechnyh arterij i ishemicheskaja bolezn’ serdca. Uchebnoe posobie. 2nd ed. Saint-Petersburg; 2012. (In Russ.)
  3. Go AS, Mozaffarian D, Roger VL, et al. Heart Disease and Stroke Statistics-2014 Update: a Report From the American Heart Association. Circulation. 2014;129(3):e28–e292. doi: 10.1161/01.cir.0000441139.02102.80
  4. Ben-Shlomo Y, Spears M, Boustred C, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol. 2014;63(7):636–646. doi: 10.1016/j.jacc.2013.09.063.80
  5. Ostroumova OD, Kochetkov AI, Kopchenov II, et al. The hardness of the vessel wall in patients with arterial hypertension. Systemic Hypertension. 2015;12(2):43–48. (In Russ.). doi: 10.26442/SG29073
  6. Korneva VA, Kuznetsova TY. Assessment of arterial wall stiffness by 24-hour blood pressure monitoring. Therapeutic Archive. 2016;88(9):119–124. (In Russ.). doi: 10.17116/terarkh2016889119-124
  7. Fujiyoshi A, Sekikawa A, Shin C, et al. A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese Americans, and U.S. whites. Eur Heart J Cardiovasc Imaging. 2013;14(9):921–927. doi: 10.1093/ehjci/jet080
  8. Zachariah JP, Hwang S, Hamburg NM, et al. Circulating adipokines and vascular function: cross-sectional associations in a community-based cohort. Hypertension. 2016;67(2):294–300. doi: 10.1161/HYPERTENSIONAHA.115.05949
  9. Rossi P, Francès Y, Kingwell B, Ahimastos A. Gender differences in artery wall biomechanical properties throughout life. J Hypertens. 2011;29(6):1023–1033. doi: 10.1038/hr.2010.25
  10. Doonan RJ, Hausvater A, Scallan C, et al. The effect of smoking on arterial stiffness. Hypertens Res. 2010;33(5):398–410. doi: 10.1038/hr.2010.25
  11. Angoff R, Mosarla RC, Tsao CW. Aortic stiffness: epidemiology, risk factors, and relevant biomarkers. Front Cardiovasc Med. 2021;8:709396. doi: 10.3389/fcvm.2021.709396
  12. Laurent S, Boutouyrie P. Vascular ageing – state of play, gaps and key issues. Heart Lung Circ. 2021;30(11):1591–1594. doi: 10.1016/j.hlc.2021.06.528
  13. Gumerova VE, Sayganov SA, Gomonova VV. Parameters of arterial stiffness in hypertensive patients with and without subclinical carotid atherosclerosis. Arterial Hypertension. 2021;27(4):427–435. (In Russ.). doi: 10.18705/1607-419X-2021-27-4-427-435
  14. Fernández-Friera L, Penalvo J, Fernandez-Ortis A, et al. Prevalence, vascular distribution, and multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort the PESA (Progression of Early Subclinical Atherosclerosis) study. Circulation. 2015;131(24):2104–2113. doi: 10.1161/CIRCULATIONAHA.114.014310
  15. Zhang Y, Fang X, Hua Y, et al. Carotid artery plaques, carotid intima–media thickness, and risk of cardiovascular events and all-cause death in older adults: A 5-Year Prospective, Community-Based Study. Angiology. 2018;69(2):120–129. doi: 10.1177/0003319717716842
  16. Shalnova SA, Deev AD. Russian mortality trends in the early XXI centure: official statistics data. Cardiovascular Therapy and Prevention. 2011;10(6):5–10. (In Russ.). doi: 10.15829/1728-8800-2011-6-5-10

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Analysis of pulse wave velocity in aorta depending on the status of smoking

Download (97KB)
Indexing metadata
3. Fig. 2. Analysis of pulse wave velocity in the aorta depending on the presence of cardiovascular diseases in the family history

Download (109KB)
Indexing metadata

Copyright (c) 2022 Sayganov S.A., Gumerova V.E., Gomonova V.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies