Transcutaneous oxegen measurement in the area of soft tissue radiation-induced fibrosis in patients with breast cancer

Cover Page

Cite item

Full Text

Abstract

Late radiation injury in the form of radiation-induced fibrosis is one of the many complications of radiation therapy. In current literature, pathogenesis of radiation-induced fibrosis is considered from several angles. According to one of the hypotheses, the main cause of pathogenesis of radiation-induced fibrosis is damage of the blood vessels caused by radiation. Another hypothesis insists that radiation causes depletion of specific cell populations in the irradiated area, reducing the number of stem cells (mostly, fibroblasts).

Based on our first-hand experience in treating late radiation injures of soft tissues in patients with breast cancer, we measured oxygen perfusion of the skin (TсPО2) in the area of late radiation injury using a transcutaneous monitor TCM 400 (Radiometer, Denmark). The obtained results may give a new insight into pathogenesis of late radiation injures.

About the authors

E. E. Topuzov

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

T. T. Agishev

Leningrad Regional Oncology Dispensary

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

K. A. Fedorov

Leningrad Regional Oncology Dispensary

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

D. A. Krasnozhon

Leningrad Regional Oncology Dispensary

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

A. B. Vats

Leningrad Regional Oncology Dispensary

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

D. V. Romanovsky

Leningrad Regional Oncology Dispensary

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

G. A. Dashyan

N.N. Petrov Research Institute of Oncology

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

A. A. Sidikov

Saint Petersburg State Pediatric Medical University

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

A. A. Ovsyannikov

North-Western State Medical University named after I.I. Mechnikov

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

S. N. Sadygova

North-Western State Medical University named after I.I. Mechnikov

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

E. V. Prikhod’ko

North-Western State Medical University named after I.I. Mechnikov

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

M. H. Kasyanova

North-Western State Medical University named after I.I. Mechnikov

Email: tagishev@gmail.com
Russian Federation, Saint Petersburg

References

  1. Топузов Э.Э. Агишев Т.Т., Божок А.А., и др. Клинико-морфологическая характеристика повреждений кожи и подкожно-жировой клетчатки после хирургического лечения и лучевой терапии у больных раком молочной железы // Опухоли женской репродуктивной системы. - 2017. - Т. 13. - № 1. - С. 25-33. [Topuzov EE, Agishev TT, Bozhok AA, et al. Clinical and morphological characteristics of skin and subcutaneous fat damage after surgical treatment and radiation therapy in patients with breast cancer. Tumors of female reproductive system. 2017;13(1):25-33. (In Russ.)]. doi: 10.17650/1994-4098-2017-13-1-25-33.
  2. Van de Steen J, Soete G, Storme G. Adjuvant radiotherapy for breast cancer significantly improves overall survival: the missing link. Radiother Oncol. 2000;55:616-623. PMID: 10869741.
  3. Herskind C, Bamberg М, Rodemann H. The role of cytokines in the development of normal-tissue reactions after radiotherapy. Strahlenther Onkol. 1998;174:12-15. PMID: 9830449.
  4. Sullivan B, Wilfred L. Late radiation-related fibrosis: pathogenesis, manifestations, and current management. Seminars in Radiation Oncolog. 2003;(3):274-289.
  5. Труфанов Г.Е., Асатурян М.А., Жаринов Г.М. Лучевая терапия: учебник. - М.: ГЭОТАР-Медиа, 2010. - Т. 2. - C. 15-185. [Trufanov GE, Asaturyan MA, Zharinov GM. Radiation therapy: Textbook. Vol. 2. Moscow: GEOTAR-Media; 2010. (In Russ.)]
  6. Вишневский А.А., Рудаков С.С., Миланов Н.О. Течение раневого процесса при местных лучевых повреждениях. - Доступно: http://medbe.ru/materials/khirurgiya-grudnoy-kletki/techenie-ranevogo-protsessa-pri-mestnykh-luchevykh-povrezhdeniyakh. [Vishnevskiy AA, Rudakov SS, Milanov NO. Course of wound process in local radiation injury. Available at: http://medbe.ru/materials/khirurgiya-grudnoy-kletki/techenie-ranevogo-protsessa-pri-mestnykh-luchevykh-povrezhdeniyakh/. (In Russ.)]
  7. Reinke JM, Sorg Н. Wound Repair and Regeneration. Н EurSurg Res. 2012;49:35-43. doi: 10.1159 / 0003.
  8. Сайт официального представителя компании Radiometer в России. - Доступно: https://www.radiometer.ru/ru-ru/clinical-settings/vascular-diagnostics-and-wound-care. [The site of the official representative of Radiometer in Russia. https://www.radiometer.ru/ru-ru/clinical-settings/vascular-diagnostics-and-wound-care].
  9. Цыб А.Ф. Местные лучевые повреждения. - М.: Медицина, 1985. - С. 240. [Tsyb AF. Local radiation injury. Moscow: Meditsina; 1985. P. 240. (In Russ.)]
  10. Epstein JB, Emerton S, Gugliett A, et al. Assessment of epidermal growth factor in oral secretions of patients receiving radiation therapy for cancer. Oral Oncol. 1997;5:359-363. PMID: 9415337
  11. Курпешев О.К. Радиобиологический анализ развития ранних и поздних лучевых повреждений // Медицинская радиология. - 1984. - № 3. - С. 54-64. [Kurpeshev OK. Radiobiological analysis of early and late radiation injury development. Medical Radiology. 1984;29(3):54-64. (In Russ.)]
  12. Medrado АP, Santos ET, Reis SR, et al. Influence of laser photobiomodulation upon connective tissue remodeling during wound healing. J PhotochemPhotobiol. 2008;92:144-152. PMID: 18602833. doi: 10.1016/j.jphotobiol.2008.05.008.
  13. Johnson LB, Jorgensen LN, Adawi D, et al. The effect of preoperative radiotherapy on systemic collagen deposition and postoperative infective complications in rectal cancer patients. Dis Colon Rectum. 2005;48:1573-1580. doi: 10.1007/S10350-005-0066-0. PMID: 15937620.
  14. Васильев В.С., Васильев С.А., Карпов И.А. Роль аутотрансплантации жировой ткани в лечении лучевых повреждений мягких тканей // Вестник ЮУрГУ. - 2013. - № 3. - С. 124. [Vasiliev VS, Vasiliev SA, Karpov IA, et al. The role of fat grafting in treatment of radiation-induced damage of soft tissue. Bulletin of the South Ural State University. Education, Healthcare, Sport series. 2013;(3):214. (In Russ.)]
  15. Sheffield P.J. Меasuring tissue oxigen tension: a review. Undesea Hyper Med. 1998;25:179-188.
  16. Крупаткин А.И. Неинвазивная оценка тканевого дыхания человека с использованием вейвлет-анализа колебаний сатурации крови кислородом кровотока в микрососудах кожи // Физиология человека. - 2012. - Т. 38. - № 4. - С. 67. [Krupatkin AI. Noninvasive estimation of human tissue respiration with wavelet-analysis of oxygen saturation and blood flow oscillations in skin microvessels. Human Physiology. 2012;38(4):67. (In Russ.)]
  17. Restrepo RD, Hirst KR, Wittnebel L, Wettstein R. AARC Clinical Practice Guideline: Transcutaneous Monitoring of Carbon Dioxide and Oxygen: 2012. Respiratory Care. 2012;57(11)1955-1962. doi: 10.4187/respcare.02011.
  18. Veronesi U, Оrecchia R, Luini A, et al. Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery. Annal of Surgery. 2005;242:101-106. doi: 10.1097/01.sla.0000167927.82353.bc. PMID: 15973107.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Principle of operation of a transcutaneous monitor (adapted from the www.radiometer.ru)

Download (259KB)
Indexing metadata
3. Fig. 2. Determination of oxygen perfusion in the radiation-induced fibrosis area in a patient with breast cancer

Download (243KB)
Indexing metadata
4. Fig. 3. Determination of oxygen perfusion the healthy tissue in a patient with breast cancer

Download (234KB)
Indexing metadata
5. Fig. 4. Mean tacross skinО2 value, mmHg: 1 — tissues with late radiation injury; 2 — healthy tissues

Download (45KB)
Indexing metadata

Copyright (c) 2018 Topuzov E.E., Agishev T.T., Fedorov K.A., Krasnozhon D.A., Vats A.B., Romanovsky D.V., Dashyan G.A., Sidikov A.A., Ovsyannikov A.A., Sadygova S.N., Prikhod’ko E.V., Kasyanova M.H.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).