Mineralocorticoid functional of adrenal cortex in patients with pheochromocytoma

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The article presents the analysis of renin–angiotensin system and content precursor of aldosterone and their metabolites, investigated by methods of high-performance liquid chromatography and gas chromatography – mass-spectrometry in 49 patients with pheochromocytoma (РНЕО) and 28 patients with non-active adenoma of the adrenal cortex and 26 healthy people. In the group of patients with PHEO the increased blood levels оf aldosterone and urine excretion of 18-hydroxycorticosterone, tetrahydrocorticosterone and it 5-α form were obtained. These patients had features of hyporeninemic and hyperreninemic hyperaldosteronism. Positive correlations of urinary excretion of free normetanephrine with blood aldosterone, renin, corticosterone and 18-hydroxycorticosterone suggest the relationship between adrenal cortex and medulla.

About the authors

N. V. Vorokhobina

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: natvorokh@mail.ru
Russian Federation, Saint Petersburg

M. A. Ivanushko

North-Western State Medical University named after I.I. Mechnikov

Email: natvorokh@mail.ru
Russian Federation, Saint Petersburg

L. I. Velikanova

North-Western State Medical University named after I.I. Mechnikov

Email: natvorokh@mail.ru
Russian Federation, Saint Petersburg

S. B. Shustov

Military Medical Academy named after S.M. Kirov

Email: natvorokh@mail.ru
Russian Federation, Saint Petersburg

Z. R. Shafigullina

North-Western State Medical University named after I.I. Mechnikov

Email: natvorokh@mail.ru
Russian Federation, Saint Petersburg

A. A. Lisitsyn

North-Western State Medical University named after I.I. Mechnikov

Email: natvorokh@mail.ru
Russian Federation, Saint Petersburg

References

  1. Трошина Е.А., Бельцевич Д.Г., Юкина М.Ю. Лабораторная диагностика феохромоцитомы // Проблемы эндокринологии. – 2010. – № 4. – С. 39–43. [Troshina EA, Bel’tsevich DG, Iukina MIu. Laboratory diagnostics of pheochromocytoma. Problems of Endocrinology. 2010;(4):39-43. (In Russ.)]
  2. Václavik J, Stejskal D, Lacnák B, et al. Free plasma metanephrines as a screening test for pheochromocytoma in low-risk patients. J Hypertens. 2007;25:1427-1431. doi: 10.1097/HJH.0b013e32813aeb5a.
  3. Ветшев П.С., Симоненко Л.И., Ипполитов С.П., и др. Феохромоцитома: клиника, диагностика, хирургическое лечение // Анналы хирургической гепатологии. – 2003. – Т. 8. – № 2. – С. 48–55. [Vetshev PS, Simonenko VB, lppolitov LJ, et al. Pheochromocytoma: Clinical Course, Diagnostics and Surgical Treatment. Annals of HPB surgery. 2003;8(2):48-55. (In Russ.)]
  4. Ein SH, Pullerits J, Creighton R, Balfe JW. Pediatric pheochromocytoma. A 36-year review. Pediat Surg Int. 1997;12(8):595-598. doi: 10.1007/BF01371907.
  5. Mannelli M, Lenders WM, Pacak MD, et al. Subclinical Phaeochromocytoma. Clinical Endocrinology and Metabolism. 2012;26(4):507-515.
  6. Tan GH, Carney JA, Grant CS, Young WF Jr, et al. Coexistence of bilateral adrenal phеochromocytoma and idiopathic hyperaldosteronism. Clin Endocrinol. 1996;44(5):603-609. doi: 10.1046/j.1365-2265.1996. 709530.x.
  7. Willa A, Hsueh WA. New insights into the medical management of primary aldosteronism. Hypertension. 1986;8:76-82. doi: 10.1161/01.HYP.8.1.76.
  8. Gordon RD, Bachmann AW, Klemm SA, et al. An association of primary aldosteronism and adrenaline-secreting phaeochromocytoma. Clin Exp Pharm Physiol. 1994;21(3):219-222.
  9. Maebashi M, Miura Y, Yoshinaga K, Sato K. Plasma renin activity in pheochromocytoma. Jap Circ J. 1968;32(10):1427-1432.
  10. Vetter H, Vetter W, Warnholz C, et al. Renin and aldosterone secretion on pheochromocytoma. Effect of chronic alpha-adrenergic receptor blockade. Am J Med. 1976;60(6):866-871.
  11. Michelakis AM, Caudle J, Liddle GW. In vitro stimulation of rennin production by epinephrine, norepinephrine, and cyclic AMP. Proc Soc Exp Biol Med. 1969;130:748-753.
  12. Ohta Y, Sakata S, Miyata E, et al. Case report: Coexistence of pheochromocytoma and bilateral aldosterone-producing adenomas in a 36-year-old woman. J Hum Hypertens. 2010;24(8):555-557. doi: 10.1038/jhh.2010.30.
  13. Reid IA, Morris BS, Ganong WF. The rennin-angiotensin system. Ann Rev Pyhsiol. 1978;40:377-410.
  14. Bornstein SR, Stratakis CA, Chrousos GP. Adrenocortical tumors: recent advances in basic concepts and clinical management. Ann Intern Med. 1999;130:759-771.
  15. Bernini M, Bacca A, Casto G, et al. A case of pheochromocytoma presenting as secondary hyperaldosteronism, hyperparathyroidism, diabetes and proteinuric renal disease. Nephrology Dialysis Transplantation. 2011;26(3):1104-1107. doi: 10.1093/ndt/gfq747.
  16. Hsieh BS, Chen FW, Hsu HC, et al. Hyperaldosteronism with coexistence of adrenal cortical adenoma and phaeochromocytoma. Taiwan I Hsueh Hui Tsa Chih. 1979;78:445-451.
  17. Landsberg L, Young JB. Catecholamines and the adrenal medulla. 8th ed. Williams Textbook of Endocrinology. 1992. P. 621-705.
  18. Великанова Л.И., Стрельникова Е.Г., Объедкова Е.В., и др. Получение cтероидных профилей мочи больных с инциденталомой надпочечников методом газовой хромато-масс-спектрометрии // Журнал аналитической химии. – 2016. – Т. 71. – № 7. – С. 775–781. [Velikanova LI, Strel’nikova EG, Obedkova EV, et al. Generation of urinary steroid profiles in patients with adrenal incidentaloma using gas chromatography-mass spectrometry. Journal of Analytical Chemistry. 2016;71(7):775-781. (In Russ.)]. doi: 10.7868/S0044450216070161.

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Copyright (c) 2018 Vorokhobina N.V., Ivanushko M.A., Velikanova L.I., Shustov S.B., Shafigullina Z.R., Lisitsyn A.A.

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