THE PARTICIPATION OF IMMUNE AND INFLAMMATORY MECHANISMSIN THE PATHOGENESIS OF CORONARY ATHEROSCLEROSIS
- Authors: Mazurov VI1, Stolov SV1, Belyaeva IB1, Trofimov EA1
-
Affiliations:
- North-Western State Medical University named after I.I. Mechnikov
- Issue: Vol 7, No 4 (2015)
- Pages: 13-23
- Section: Reviews
- URL: https://journals.rcsi.science/vszgmu/article/view/8519
- DOI: https://doi.org/10.17816/mechnikov20157413-23
- ID: 8519
Cite item
Abstract
It was revealed that in development of a coronary atherosclerosis, participate the immune-mediated mechanisms. In blood of patients with coronary atherosclerosis the maintenance of the basic classes cytokines (IL-1 β, IL-2, IL-6, IL-8, TNF-a) were increased. Development of acute coronary insufficiency is accompanied by additional increase of levels of the data cytokines. The accessory of the cytokine activity to a coronary atherosclerosis was confirmed at studying the maintenance mRNA cytokines in a vascular wall. Thus in a zone atheromatous (aorta) it was synthesized mainly mRNA IL-2, while in a zone lipomatosis (a beam radial artery) it is formed nonspecific immune reaction with development of the mRNA IL-1 and IL-6. For patients with rheumatoid arthritis typically more active defeat of a coronary arteries, in comparison with healthy persons. Chronic immune-mediated process in frameworks of the autoimmune pathology can serve a trigger for accelerated development ischemic heart disease. The General immune-inflammatory mechanisms which participate in pathogenesis of the ischemic heart disease and rheumatoid arthritis, allow to spend the certain parallels between atherosclerotic process and autoimmune pathology.
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##article.viewOnOriginalSite##About the authors
V I Mazurov
North-Western State Medical University named after I.I. Mechnikov
S V Stolov
North-Western State Medical University named after I.I. Mechnikov
I B Belyaeva
North-Western State Medical University named after I.I. Mechnikov
E A Trofimov
North-Western State Medical University named after I.I. Mechnikov
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