Disseminated seronegative echinococcosis: difficulties of diagnosis and treatment

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Abstract

Disseminated seronegative echinococcosis, occurring with damage to soft tissues, bones and joints, is a rare variant of the course of helminthiasis, often associated with diagnostic difficulties, a high probability of complications and difficult treatment.

This article presents a case of disseminated seronegative echinococcosis, clinically and laboratory simulating a severe form of Weber–Christian panniculitis complicated by sepsis. The advantages and disadvantages of serological and morphological studies in the verification of disseminated echinococcosis are discussed, as well as the feasibility of using repeated histological studies in cases of echinococcosis under the masks of rheumatic diseases.

About the authors

Vadim I. Mazurov

Clinical Rheumatology Hospital No. 25; North-Western State Medical University named after I.I. Mechnikov

Email: maz.nwgmu@yandex.ru
ORCID iD: 0000-0002-0797-2051
SPIN-code: 6823-5482
ResearcherId: J-9643-2014

MD, Dr. Sci. (Med.), Professor, Academician of the RAS, Honored Scientist of the Russian Federation

Russian Federation, Saint Petersburg; Saint Petersburg

Inna Z. Gaidukova

Clinical Rheumatology Hospital No. 25; North-Western State Medical University named after I.I. Mechnikov

Email: ubp1976@list.ru
ORCID iD: 0000-0003-3500-7256
SPIN-code: 3083-7996
Scopus Author ID: 55237525900
ResearcherId: F-6020-2013

MD, Dr. Sci. (Med.), Professor

Russian Federation, Saint Petersburg; Saint Petersburg

Elena E. Nochvay

Clinical Rheumatology Hospital No. 25

Email: b25@zdrav.spb.ru
ORCID iD: 0000-0002-8636-5961

MD

Russian Federation, Saint Petersburg

Marianna S. Petrova

Clinical Rheumatology Hospital No. 25; North-Western State Medical University named after I.I. Mechnikov

Email: alek-bychkova@yandex.ru
ORCID iD: 0000-0001-5261-6614

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg; Saint Petersburg

Oksana V. Inamova

Clinical Rheumatology Hospital No. 25; North-Western State Medical University named after I.I. Mechnikov

Email: alek-bychkova@yandex.ru
ORCID iD: 0000-0001-9126-3639
SPIN-code: 8841-5496

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg; Saint Petersburg

Sergey O. Mazurenko

North-Western District Scientific and Clinical Center named after L.G. Sokolov Federal Medical and Biological Agency; Saint Petersburg State University

Email: b4@zdrav.spb.ru
ORCID iD: 0000-0002-1915-2237
SPIN-code: 2764-6326
Scopus Author ID: 57189031088
ResearcherId: J-8829-2013

MD, Dr. Sci. (Med.), Professor

Russian Federation, Saint Petersburg; Saint Petersburg

Yulia A. Petrova

Mariinsky Hospital

Email: b16@mariin.ru
ORCID iD: 0000-0002-2675-392X

MD

Russian Federation, Saint Petersburg

Alexandra S. Bychkova

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: alek-bychkova@yandex.ru
ORCID iD: 0000-0002-6275-2123
SPIN-code: 7615-0120
Russian Federation, Saint Petersburg

Sergey L. Vorobyev

National Center for Clinical Morphological Diagnostics

Email: ncmd@ncmd.ru
ORCID iD: 0000-0002-7817-9069
SPIN-code: 5920-0603

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

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2. Fig. 1. Skin changes of the patient’s lower extremities

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3. Fig. 2. Focal destructive and infiltrative changes in the bones and soft tissues of the patient’s knee joints (according to computed tomography)

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4. Fig. 3. Histological examination of the musculoskeletal flap of the patient’s right thigh, hematoxylin-eosin staining. Hydatides with a distinct chitinous shell and perifocal calcification are identified; preserved scolexes in the lumen of a part of the hydatides are identified

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Copyright (c) 2022 Mazurov V.I., Gaidukova I.Z., Nochvay E.E., Petrova M.S., Inamova O.V., Mazurenko S.O., Petrova Y.A., Bychkova A.S., Vorobyev S.L.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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