Comparative analysis of the course of COVID-19 and post-COVID syndrome in patients with inflammatory bowel disease and COVID-19 caused by the Omicron strain and earlier strains
- Authors: Kupkenova L.M.1,2, Odintsova A.K.2, Iskhakova D.G.3, Cheremina N.A.2, Abdulganieva D.I.1,2
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Affiliations:
- Kazan State Medical University
- Republican Clinical Hospital
- City Clinical Hospital No. 7
- Issue: Vol 15, No 2 (2023)
- Pages: 39-48
- Section: Original research
- URL: https://journals.rcsi.science/vszgmu/article/view/131103
- DOI: https://doi.org/10.17816/mechnikov120007
- ID: 131103
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Abstract
BACKGROUND: Patients with inflammatory bowel disease have specific features of the course of COVID-19 and post-COVID syndrome. The available literature is limited in data comparing the course of COVID-19 of different strains in patients with inflammatory bowel disease as well as assessing the course of post-COVID syndrome.
AIM: To conduct a comparative analysis of the course of COVID-19 and post-covid syndrome in patients with inflammatory bowel disease and COVID-19 caused by the Omicron strain and earlier strains.
MATERIALS AND METHODS: The study included 159 patients diagnosed with ulcerative colitis and Crohn’s disease and COVID-19, who were observed in two temporary infectious diseases hospitals in Kazan (Republican Clinical Hospital and City Clinical Hospital No. 7) and on outpatient basis since April 2020 to May 2022. For a comparative analysis of the course of COVID-19 and post-COVID syndrome in patients who had come through COVID-19, 2 periods were defined: the 1st period — from March 2020 to December 2021, the 2nd period — from January 2022.
RESULTS: None of the patients with Omicron developed lung damage (0 (0%) vs 36 (44.4%), p < 0.05). It has been also found that among patients with Omicron there were more patients with comorbidity (62 (79.5%) versus 50 (61.7%), (p < 0.05).
Dynamic observation of the patients has revealed that post-covid syndrome was significantly less common in the patients with Omicron for 3 months after COVID-19 (25.6% vs. 47.1%).
When analyzing the complaints associated with asthenia, it was found that they were significantly more common in the patients with Omicron 3 months after COVID-19 (58 (74.3%) in comparison with 17 (50%), p < 0.05). The complaints associated with cognitive impairment (0 (0%) vs. 3 (8.8%), p < 0.05) and depression (Hospital Anxiety and Depression Scale (31 (39.7%) vs. 22 (64.7%), p < 0.05), Hamilton scale (22 (28.2%) vs. 22 (64.7%), p < 0.05)) were significantly less common in the patients with Omicron for 3 months after COVID-19.
After analyzing the activity in the patients with inflammatory bowel disease before COVID-19 and 3, 6, 9 months after COVID-19, we have found that the maximum number of patients with the exacerbation of inflammatory bowel disease was noted after 3 months in the patients with Omicron and after 6 months in the patients with earlier strains.
CONCLUSIONS: Thus, the results of the study have shown that in the patients with inflammatory bowel disease, both in ulcerative colitis and Crohn’s disease, the course of COVID-19 caused by the Omicron strain proceeded in a milder form compared with the patients who had earlier strains. In the patients with Omicron, complaints characteristic of post-COVID syndrome were less common. After a previous infection with COVID-19, the frequency of inflammatory bowel disease relapses increased: in the patients with Omicron due to mild exacerbation 3 months after COVID-19; in the patients with earlier strains — due to moderate and severe relapse.
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##article.viewOnOriginalSite##About the authors
Luciya M. Kupkenova
Kazan State Medical University; Republican Clinical Hospital
Author for correspondence.
Email: lkupkenova@mail.ru
ORCID iD: 0000-0003-2874-9462
SPIN-code: 1388-9222
MD
Russian Federation, 49 Butlerova St., Kazan, 420012; KazanAlfiya Kh. Odintsova
Republican Clinical Hospital
Email: odincovaa@yandex.ru
ORCID iD: 0000-0002-7148-8862
MD, Cand. Sci. (Med.)
Russian Federation, KazanDilyara G. Iskhakova
City Clinical Hospital No. 7
Email: iskhakova_d@mail.ru
ORCID iD: 0000-0003-3829-5302
MD
Russian Federation, KazanNatalya A. Cheremina
Republican Clinical Hospital
Email: doctornat@mail.ru
ORCID iD: 0000-0002-5856-5050
MD
Russian Federation, KazanDiana I. Abdulganieva
Kazan State Medical University; Republican Clinical Hospital
Email: diana_s@mail.ru
ORCID iD: 0000-0001-7069-2725
SPIN-code: 6676-4270
MD, Dr. Sci. (Med.), Professor
Russian Federation, 49 Butlerova St., Kazan, 420012; KazanReferences
- Hu J, Peng P, Cao X, et al. Increased immune escape of the new SARS-CoV-2 variant of concern Omicron. Cell Mol Immunol. 2022;19(2):293–295. doi: 10.1038/s41423-021-00836-z
- Statistika rasprostraneniya shtammov COVID-19 [Internet]. Available from: https://yandex.ru/covid19/stat?ysclid=lailguacx3698961331. Accessed: 14.11.2022. (In Russ.)
- Wolter N, Jassat W, Walaza S, et al. Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study. Lancet. 2022;399(10323):437–446. doi: 10.1016/S0140-6736(22)00017-4
- Maslo C, Friedland R, Toubkin M, et al. Characteristics and outcomes of hospitalized patients in South Africa during the COVID-19 Omicron wave compared with previous waves. JAMA. 2022;327(6):583–584. doi: 10.1001/jama.2021.24868
- Houhamdi L, Gautret P, Hoang VT, et al. Characteristics of the first 1119 SARS-CoV-2 Omicron variant cases, in Marseille, France, November-December 2021. J Med Virol. 2022;94(5):2290–2295. doi: 10.1002/jmv.27613
- Menni C, Valdes AM, Polidori L, et al. Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study. Lancet. 2022;399(10335):1618–1624. doi: 10.1016/S0140-6736(22)00327-0
- Macaluso FS, Giuliano A, Fries W, et al. Severe activity of inflammatory bowel disease is a risk factor for severe COVID-19. Inflamm Bowel Dis. 2023;29(2):217–221. doi: 10.1093/ibd/izac064
- Lin S, Lau LH, Chanchlani N, et al. Recent advances in clinical practice: management of inflammatory bowel disease during the COVID-19 pandemic. Gut. 2022;71(7):1426–1439. doi: 10.1136/gutjnl-2021-326784
- Esposito S, Caminiti C, Giordano R, et al. Risks of SARS-CoV-2 infection and immune response to COVID-19 vaccines in patients with inflammatory bowel disease: current evidence. Front Immunol. 2022;13:933774. doi: 10.3389/fimmu.2022.933774
- Briko NI, Korshunov VA, Krasnova SV, et al. Clinical and epidemiological characteristics of hospitalized patients with COVID-19 during different pandemic periods in Moscow. Journal of microbiology, epidemiology and immunobiology. 2022;99(3):287–299. (In Russ.) doi: 10.36233/0372-9311-272
- Rasprostranenie COVID-19 v Respublike Tatarstan po dannym Rospotrebnadzora [Internet]. Available from: https://16.rospotrebnadzor.ru/?ysclid=lbluw2ffhr135904308. Accessed: 20.12.2022. (In Russ.)
- Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn’s disease activity index. National Cooperative Crohn’s Disease Study. Gastroenterology. 1976;70(3):439–444.
- Truelove SC, Witts LJ. Cortisone in ulcerative colitis; preliminary report on a therapeutic trial. Br Med J. 1954;(2):375–378. doi: 10.1136/bmj.2.4884.375
- Prikaz Ministerstva zdravookhraneniya Rossiiskoi Federatsii ot 01.07.2021 № 698n “Ob utverzhdenii Poryadka napravleniya grazhdan na prokhozhdenie uglublennoi dispanserizatsii, vklyuchaya kategorii grazhdan, prokhodyashchikh uglublennuyu dispanserizatsiyu v pervoocherednom poryadke”. (In Russ.)
- Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–370. doi: 10.1111/j.1600-0447.1983.tb09716.x
- The Hamilton rating scale for depression [Internet]. Available from: https://web.archive.org/web/20071120002356/http://healthnet.umassmed.edu/mhealth/HAMD.pdf. Accessed: 13.11.2022.
- Zolotovskaia IA, Shatskaia PR, Davydkin IL, Shavlovskaya OA. Post-COVID-19 asthenic syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(4):25–30. (In Russ.) doi: 10.17116/jnevro202112104125
- Finney GR, Minagar A, Heilman KM. Assessment of mental status. Neurol Clin. 2016;34(1):1–16. doi: 10.1016/j.ncl.2015.08.001