Botulinum toxin type A in the treatment of bladder pain syndrome in women: initial results

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Abstract

We present the results of botulinum toxin type A (BT-A) treatment in 49 women (aged 41–65 years) with bladder pain syndrome. Previously, all patients underwent oral and intravesical drug therapy in addition to hydrodistention of the bladder without significant clinical effect. BT-A at a dose of 100 U (20 points at 5 units) was injected into the bladder under general anesthesia. Treatment results were evaluated 3 months after the treatment using specialized questionnaires such as the Pelvic Pain and Urgency/Frequency (PUF) Scale, O’Leary-Sant Symptom Index and Interstitial Cystitis Scale, visual analogue pain scale (VAS), and urinary diaries. Remarkably, the treatment was effective in 46 (93.8%) patients. By the end of the third month after the BT-A injection, the PUF Scale score, the O’Leary-Sant Symptom and Interstitial Cystitis Scale, and VAS reduced by 41.3%, 32%, and 34%, respectively, and urination frequency decreased by 38.5%. Thus, BT-A is an effective method for treating bladder pain syndrome in patients who are refractory to other treatment methods.

About the authors

Salman H. Al-Shukri

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: alshukri@mail.ru

Doctor of Medical Science, Professor, Head of the Department of Urology

Russian Federation, Saint Petersburg

Igor V. Kuzmin

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation

Email: kuzminigor@mail.ru

Doctor of Medical Science, Professor, Department of Urology

Russian Federation, Saint Petersburg

Margarita N. Slesarevskaya

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation

Email: mns-1971@yandex.ru

Candidate of Medical Science, Senior Research Fellow, Department of Urology

Russian Federation, Saint Petersburg

Yuriy A. Ignashov

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation

Email: yuri.ignashov@gmail.com

Postgraduate, Department of Urology

Russian Federation, Saint Petersburg

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Copyright (c) 2018 Al-Shukri S.H., Kuzmin I.V., Slesarevskaya M.N., Ignashov Y.A.

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