Male infertility, metabolic syndrome and obesity

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Abstract

The review article is devoted to the current understanding of the mechanisms that can have a negative impact on the reproductive function of men with metabolic syndrome and obesity. The article presents the results of clinical studies proving the existence of a relationship between the severity of metabolic disorders, copulatory activity, ejaculate parameters, the likelihood of pregnancy, as well as the health of the offspring.

About the authors

Igor A. Korneyev

Academician I.P. Pavlov First St. Petersburg State Medical University; International Centre for Reproductive Medicine

Author for correspondence.
Email: iakorneyev@yandex.ru
ORCID iD: 0000-0001-7347-1901
SPIN-code: 4780-2266
Scopus Author ID: 6506000592
ResearcherId: R-3046-2017
https://professiya-vrach.ru/heroes/sankt-peterburg/korneev-igor-alekseevich/

Dr. Sci. (Med), Professor of the Department of Urology, center director

Russian Federation, 6-8 L’va Tolstogo str., Saint Petersburg, 197022; 53/1A, Komendantsky Prospect, Saint-Petersburg, 197371

Irina A. Matsueva

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: irina.macueva.98@mail.ru

student

Russian Federation, 6-8 L’va Tolstogo str., Saint Petersburg, 197022

References

  1. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Bio lEndocrinol. 2015;13:37. doi: 10.1186/s12958-015-0032-1
  2. Levine H, Jorgensen N, Martino-Andrade A, et al. Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update. 2017;23(6):646–659. doi: 10.1093/humupd/dmx022
  3. Lebedev GS, Golubev NA, Shaderkin IA, et al. Male infertility in the Russian Federation: statistical data for 2000–2018. Experimental and Clinical Urology 2019;(4):4–13. (In Russ.) doi: 10.29188/2222-8543-2019-11-4-4-12
  4. Skakkebaek NE, Rajpert-DeMeyts E, BuckLouis GM, et al. Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility. Physiol Rev. 2016;96(1):55–97. doi: 10.1152/physrev.00017.2015
  5. Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep. 2018;20(2):12. doi: 10.1007/s11906-018-0812-z
  6. Rato L, Alves MG, Socorro S, et al. Metabolic regulation is important for spermatogenesis. Nat Rev Urol. 2012;9(6):330–338. doi: 10.1038/nrurol.2012.77
  7. Rato L, Meneses MJ, Silva BM, et al. New insights on hormones and factors that modulate Sertoli cell metabolism. Histol Histopathol. 2016;31(5):499–513. doi: 10.14670/HH-11-717
  8. Lotti F, Corona G, Degli Innocenti S, et al. Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples. Andrology. 2013;1(2):229–239. doi: 10.1111/j.2047-2927.2012.00031.x
  9. Lotti F, Corona G, Vignozzi L, et al. Metabolic syndrome and prostate abnormalities in male subjects of infertile couples. Asian J Androl. 2014;16(2):295–304. doi: 10.4103/1008-682X.122341
  10. Matsuzawa Y, Funahashi T, Nakamura T. The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. J Atheroscler Thromb. 2011;18(8):629–639. doi: 10.5551/jat.7922
  11. Leisegang K, Udodong A, Bouic PJ, Henkel RR. Effect of the metabolic syndrome on male reproductive function: a case-controlled pilot study. Andrologia. 2014;46(2):167–176. doi: 10.1111/and.12060
  12. Ventimiglia E, Capogrosso P, Colicchia M, et al. Metabolic syndrome in white European men presenting for primary couple’s infertility: investigation of the clinical and reproductive burden. Andrology. 2016;4(5):944–951. doi: 10.1111/andr.12232
  13. Ehala-Aleksejev K, Punab M. The effect of metabolic syndrome on male reproductive health: A cross-sectional study in a group of fertile men and male partners of infertile couples. PLoS One. 2018;13(3): e0194395. doi: 10.1371/journal.pone.0194395
  14. Chen HG, Sun B, Chen YJ, et al. Sleep duration and quality in relation to semen quality in healthy men screened as potential sperm donors. Environ Int. 2020;135:105368. doi: 10.1016/j.envint.2019.105368
  15. Meller SM, Stilip E, et al. The link between vasculogenic erectile dysfunction, coronary artery disease, and peripheral artery disease: role of metabolic factors and endovascular therapy. J Invasive Cardiol. 2013;25(6):313–319.
  16. Feldman HA, Goldstein I, Hatzichristou DG, et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. JB J Urol. 1994;151(1):54–61. doi: 10.1016/s0022-5347(17)34871-1
  17. Korneyev IA, Alexeeva TA, Al-Shukri SH, et al. Prevalence and risk factors for erectile dysfunction and lower urinary tract symptoms in Russian Federation men: analysis from a national population-based multicenter study. Int J Impot Res. 2016;28(2):74–79. doi: 10.1038/ijir.2016.8
  18. Mkrtumjan AM, Romanova EV. Metabolicheskij sindrom u muzhchin reproduktivnogo vozrasta. Jeffektivnaja farmakoterapija. Jendokrinologija. 2010;(6);46–53. (In Russ.)
  19. Jakovleva LM, Porfiriev VV. Pathogenetic aspects of male subfertility in obesity: a review of experimental and clinical studies. Urologicheskie vedomosti. 2019;9(2):37–42. (In Russ.) doi: 10.17816/uroved9237-42
  20. Wu FCW, Tajar A, Pye SR, Silman AJ. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab. 2008;93(7):2737–2745. doi: 10.1210/jc.2007-1972
  21. Moschos S, Chan JL, Mantzoros CS. Leptin and reproduction: a review. Fertil Steril. 2002;77(3):433–444. doi: 10.1016/s0015-0282(01)03010-2
  22. Lihonosov NP, Ajub AH, Babenko AJ, Borovets SYu. The role of inhibin B in the regulation of spermatogenesis and its clinical significance in male infertility. Urologicheskie vedomosti. 2019;9(1):39–45. (In Russ.) doi: 10.17816/uroved9139-45
  23. Dierich A, Sairam MR, Monaco L, et al. Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci USA. 1998;95(23):13612–13617. doi: 10.1073/pnas.95.23.13612
  24. Corona G, Rastrelli G, Monami M, et al. Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. Eur J Endocrinol. 2013;168(6):829–843. doi: 10.1530/EJE-12-0955
  25. Pasquali R. Obesity and androgens: facts and perspectives. Fertil Steril. 2006;85(5):1319–1340. doi: 10.1016/j.fertnstert.2005.10.054
  26. Le TN, Nestler JE, Strauss JF, Wickham EP. Sex hormone-binding globulin and type 2 diabetes mellitus. Trends Endocrinol Metab. 2012;23(1):32–40. doi: 10.1016/j.tem.2011.09.005
  27. Agbaje IM, Rogers DA, McVicar CM, et al. Insulin dependant diabetes mellitus: implications for male reproductive function. Hum Reprod. 2007;22(7):1871–1877. doi: 10.1093/humrep/dem077
  28. Kolotkin RL, Binks M, Crosby RD, et al. Obesity and sexual quality of life. Obesity (Silver Spring). 2006;14(3):472–479. doi: 10.1038/oby.2006.62
  29. Burn H, Gunn S, Chowdhry S, et al. Comprehensive Review and Case Study on the Management of Buried Penis Syndrome and Related Panniculectomy. Eplasty. 2018(1);18: e5
  30. Nimbi FM, Virginia C, Cinzia DM, et al. The relation between sexuality and obesity: the role of psychological factors in a sample of obese men undergoing bariatric surgery. Int J Impot Res. 2020. doi: 10.1038/s41443-020-00388-2
  31. Durairajanayagam D, Agarwal A. Causes, effects and molecular mechanisms of testicular heat stress. Reprod Biomed Online. 2015;30(1):14–27. doi: 10.1016/j.rbmo.2014.09.018
  32. Garolla A, Torino M, Paride M, Caretta N, et al. Twenty-four-hour monitoring of scrotal temperature in obese men and men with a varicocele as a mirror of spermatogenic function. Hum Reprod. 2015;30(5):1006–1013. doi: 10.1093/humrep/dev057
  33. Shafik A, Olfat S. Scrotal lipomatosis. Br J Urol. 1981;53(1): 50–54.
  34. Ramlau-Hansen CH, Thulstrup AM, Nohr EA, et al. Subfecundity in overweight and obese couples. Hum Reprod. 2007;22(6): 1634–1637. doi: 10.1093/humrep/dem035
  35. Nguyen RHN, Wilcox AJ, Skjaerven R, Baird DD. Men’s body mass index and infertility. Hum Reprod Oxf Engl. 2007;22(9): 2488–2493. doi: 10.1093/humrep/dem139
  36. Sallmén M, Sandler DP, Hoppin JA, et al. Reduced fertility among overweight and obese men. Epidemiol Camb Mass. 2006;17(5): 520–523. doi: 10.1097/01.ede.0000229953.76862.e5
  37. Epanchintseva EA, Selyatitskaya VG, Sviridova MA, Lutov YuV. Sociomedical risk factors for male infecundity. Andrology and Genital Surgery. 2016;17(3):47–53. (In Russ.) doi: 10.17650/2070-9781-2016-17-3-47-53
  38. Jensen TK, Andersson AM, Jorgensen N, et al. Body mass index in relation to semen quality and reproductive hormonesamong 1,558 Danish men. Fertil Steril. 2004;82(4):863–870. doi: 10.1016/j.fertnstert.2004.03.056
  39. Eisenberg ML, Kim S, Chen Z, et al. The relationship between male BMI and waist circumference on semen quality: data from the LIFE study. Hum Reprod Oxf Engl.2014;29(2):193–200. doi: 10.1093/humrep/deu322
  40. MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update. 2010;16(3):293–311. doi: 10.1093/humupd/dmp047
  41. Sermondade N, Faure C, Fezeu L, et al. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2013;19(3):221–231. doi: 10.1093/humupd/dms050
  42. Campbell JM, Lane M, Owens JA, Bakos HW. Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis. Reprod Biomed Online. 2015;31(5):593–604. doi: 10.1016/j.rbmo.2015.07.012
  43. Colaci DS, Afeiche M, Gaskins AJ, et al. Men’s body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization. Fertil Steril. 2012;98(5):1193–1199.e1. doi: 10.1016/j.fertnstert.2012.07.1102
  44. Moragianni VA, Jones SM, Ryley DA. The effect of body mass index on the outcomes of first assisted reproductive technology cycles. Fertil Steril. 2012;98(1):102–108. doi: 10.1016/j.fertnstert.2012.04.004
  45. Sepidarkish M, Maleki-Hajiagha A, Maroufizadeh S, et al. The effect of body mass index on sperm DNA fragmentation: a systematic review and meta-analysis. Int J Obes. 2020;44(3):549–558. doi: 10.1038/s41366-020-0524-8
  46. Keber R, Rozman D, Horvat S. Sterols in spermatogenesis and sperm maturation. J Lipid Res. 2013;54(1):20–33. doi: 10.1194/jlr.R032326
  47. Agarwal A, Parekh N, Panner Selvam MK, et al. Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility. World J Mens Health. 2019;37(3):296–312. doi: 10.5534/wjmh.190055
  48. Villaverde AISB, Netherton J, Baker MA. From Past to Present: The Link Between Reactive Oxygen Species in Sperm and Male Infertility. Antioxidants (Basel). 2019;8(12):616. doi: 10.3390/antiox8120616
  49. Rozhivanov RV, Kurbatov DG. The structure of pathozoospermia in young men with post pubertal visceral obesity and normal andrological anamnesis. Obesity and metabolism. 2017;14(4):32–37. (In Russ.) doi: 10.14341/OMET2017432-37
  50. Pujol A, Obradors A, Esteo E, Costilla B, et al. Oxidative stress level in fresh ejaculate is not related to semen parameters or to pregnancy rates in cycles with donor oocytes. J Assist Reprod Genet. 2016;33(4):529–534. doi: 10.1007/s10815-016-0660-1
  51. Smits RM, Mackenzie-Proctor R, Yazdani A, et al. Antioxidants for male subfertility. Cochrane Database Syst Rev. 2019;3(3): CD007411. doi: 10.1002/14651858.CD007411.pub4
  52. Saez Lancellotti TE, Boarelli PV, Monclus MA, et al. Hypercholesterolemia impaired sperm functionality in rabbits. PLoS One. 2010;5(10): e13457. doi: 10.1371/journal.pone.0013457
  53. Campbell JM, McPherson NO. Influence of increased paternal BMI on pregnancy and child health outcomes independent of maternal effects: A systematic review and meta-analysis. Obes Res Clin Pract. 2019;13(6):511–521. doi: 10.1016/j.orcp.2019.11.003
  54. Drapkina OM, Kim OT. Epigenetics of obesity. Cardiovascular Therapy and Prevention. 2020;19(6):94–100. (In Russ.) doi: 10.15829/1728-8800-2020-2632
  55. Donkin I, Versteyhe S, Ingerslev LR, et al. Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. Cell Metab. 2016;23(2):369–78. doi: 10.1016/j.cmet.2015.11.004
  56. Marques CJ, Costa P, Vaz B, et al. Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia. Mol Hum Reprod. 2008;14(2):67–74. doi: 10.1093/molehr/gam093
  57. van der Heijden GW, Ramos L, Baart EB, et al. Sperm-derived histones contribute to zygotic chromatin in humans. BMC Dev Biol. 2008;8:34. doi: 10.1186/1471-213X-8-34
  58. Kaati G, Bygren LO, Edvinsson S. Cardiovascular and diabetes mortality determined by nutrition during parents’ and grandparents’ slow growth period. Eur J Hum Genet. 2002;10(11):682–688. doi: 10.1038/sj.ejhg.5200859
  59. Soubry A, Murphy SK, Wang F, et al. Newborns of obese parents have altered DNA methylation patterns at imprinted genes. Int J Obes (Lond). 2015;39(4):650–657. doi: 10.1038/ijo.2013.193
  60. Pembrey ME, Bygren LO, Kaati G, et al. Sex-specific, male-line transgenerational responses in humans. Eur J Hum Genet. 2006;14(2):159–166. doi: 10.1038/sj.ejhg.5201538.

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