Stimulation of kidneys’ adaptive capabilities in patients with urolithiasis

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Abstract

Inflammatory changes in the kidney that occurred in the early postoperative period due to surgical trauma, deterioration of microcirculation, hypoxia, are significant risk factors for the development of renal function violation. The aim of this work is to study the effect of the combined drug “Uriclar” (Asfarma-Ros) on the kidneys’ adaptive capability in the early postoperative period as a response to operative trauma of patients with complicated urolithiasis. The effect of surgical intervention – percutaneous puncture nephrolithotripsy on the blood content of proteins of the acute phase of inflammation and cystatin C was studied. The results of examination of 35 patients (20 – the main group and 15 – the control group) were analyzed. The median age was 51 ± 8.4 years. 20 patients of the main group began receiving Uriclar 2 capsules (430 mg) twice a day for 5 days before surgery and continued it for 1 month after surgery. Patients from the control group in the pre- and postoperative periods didn’t receive Uriclar. The median age was 51 ± 8.4 years. There was a statistically significant increase in the level of cystatin C and changes in biochemical markers in the patients of the main group only that indicates the presence of adaptogenic effect of Uriclar. Thus, the inclusion of a combined drug Uriclar in a complex treatment of patients with urolithiasis allows disturbed biological and adaptive functions of the kidneys to be corrected in the early postoperative period.

About the authors

Olga S. Streltsova

Privolzhskiy Research Medical University

Author for correspondence.
Email: strelzova_uro@mail.ru

Doctor of Medical Science, Professor of the Department of Urology named after E.V. Shakhov

Russian Federation, Nizhny Novgorod

Dmitry P. Pochtin

Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko

Email: dpochtin@mail.ru

urologist

Russian Federation, Nizhny Novgorod

Tatiana A. Gorbunova

Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko

Email: gorbunova6030@yandex.ru

Clinical Laboratory Diagnostics Doctor

Russian Federation, Nizhny Novgorod

Valery F. Lazukin

Privolzhskiy Research Medical University

Email: valery-laz@yandex.ru

Candidate of Medical Science, Associate Professor of the Department of Medical Physics and Informatics

Russian Federation, Nizhny Novgorod

Ilya L. Sidnev

Privolzhskiy Research Medical University

Email: iljasidnev@yandex.ru

student

Russian Federation, Nizhny Novgorod

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Supplementary files

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2. Fig. 1. Distribution of cystatin С (a) and electrophoregram indices (b–f) in patients of the main (group У) and control (group K) groups before and after surgery

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3. Fig. 2. Electrophoregrams of patients in the control group – group K (a, b) and the main group – group У (c, d) before and after surgery. The peak of the β2-globulin fraction is indicated by the arrow (a, b)

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Copyright (c) 2019 Streltsova O.S., Pochtin D.P., Gorbunova T.A., Lazukin V.F., Sidnev I.L.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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